Can we improve the therapy of Clostridium difficile infection
in elderly patients?

J 2016

Can we improve the therapy of Clostridium difficile infection in elderly patients?

BIELAKOVÁ, Katarína; Emmanuela FERNANDOVÁ; Hana MATĚJOVSKÁ KUBEŠOVÁ; Pavel WEBER; Dana PRUDIUS et al.

Základní údaje

Originální název

Can we improve the therapy of Clostridium difficile infection in elderly patients?

Autoři

BIELAKOVÁ, Katarína; Emmanuela FERNANDOVÁ; Hana MATĚJOVSKÁ KUBEŠOVÁ; Pavel WEBER; Dana PRUDIUS a Josef BEDNAR

Vydání

Wiener klinische Wochenschrift, Wien, Springer Wien, 2016, 0043-5325

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.974

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00092333

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Clostridium difficile; Geriatric patient; Antibiotic therapy; Pseudomebranous colitis; Binary logistic regression model

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 12. 2016 10:12, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients' stool or an autopsy confirmation was crucial. The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients' histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients' history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever. Our logistic regression model may predict mortality in geriatric patients suffering from CDI. This could help improve the therapeutic process.

Návaznosti

MUNI/A/0945/2013, interní kód MU

Název: Prevence syndromů stáří III (Akronym: PRESYST III)

Investor: Masarykova univerzita, Prevence syndromů stáří III, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

BIELAKOVÁ, Katarína; Emmanuela FERNANDOVÁ; Hana MATĚJOVSKÁ KUBEŠOVÁ; Pavel WEBER; Dana PRUDIUS a Josef BEDNAR. Can we improve the therapy of Clostridium difficile infection in elderly patients? Wiener klinische Wochenschrift. Wien: Springer Wien, 2016, roč. 128, 15-16, s. 592-598. ISSN 0043-5325. Dostupné z: https://doi.org/10.1007/s00508-016-1056-z.

@article{1364954,
   author = {Bielaková, Katarína and Fernandová, Emmanuela and Matějovská Kubešová, Hana and Weber, Pavel and Prudius, Dana and Bednar, Josef},
   article_location = {Wien},
   article_number = {15-16},
   doi = {https://doi.org/10.1007/s00508-016-1056-z},
   keywords = {Clostridium difficile; Geriatric patient; Antibiotic therapy; Pseudomebranous colitis; Binary logistic regression model},
   language = {eng},
   issn = {0043-5325},
   journal = {Wiener klinische Wochenschrift},
   title = {Can we improve the therapy of Clostridium difficile infection in elderly patients?},
   volume = {128},
   year = {2016}
}

TY  - JOUR
ID  - 1364954
AU  - Bielaková, Katarína - Fernandová, Emmanuela - Matějovská Kubešová, Hana - Weber, Pavel - Prudius, Dana - Bednar, Josef
PY  - 2016
TI  - Can we improve the therapy of Clostridium difficile infection in elderly patients?
JF  - Wiener klinische Wochenschrift
VL  - 128
IS  - 15-16
SP  - 592-598
EP  - 592-598
PB  - Springer Wien
SN  - 00435325
KW  - Clostridium difficile
KW  - Geriatric patient
KW  - Antibiotic therapy
KW  - Pseudomebranous colitis
KW  - Binary logistic regression model
N2  - Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients' stool or an autopsy confirmation was crucial. The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients' histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients' history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever. Our logistic regression model may predict mortality in geriatric patients suffering from CDI. This could help improve the therapeutic process.
ER  -

BIELAKOVÁ, Katarína; Emmanuela FERNANDOVÁ; Hana MATĚJOVSKÁ KUBEŠOVÁ; Pavel WEBER; Dana PRUDIUS a Josef BEDNAR. Can we improve the therapy of Clostridium difficile infection in elderly patients? \textit{Wiener klinische Wochenschrift}. Wien: Springer Wien, 2016, roč.~128, 15-16, s.~592-598. ISSN~0043-5325. Dostupné z: https://doi.org/10.1007/s00508-016-1056-z.

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