Irreversible electroporation with endoluminal balloon
catheterin perihilar region: preliminary results

a 2016

Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results

ANDRAŠINA, Tomáš, Jiří PÁNEK, Dalibor ČERVINKA, Iva SVOBODOVÁ, Martin Jakub ARBET et. al.

Základní údaje

Originální název

Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results

Autoři

ANDRAŠINA, Tomáš (703 Slovensko, garant, domácí), Jiří PÁNEK (203 Česká republika, domácí), Dalibor ČERVINKA (203 Česká republika), Iva SVOBODOVÁ (203 Česká republika, domácí) a Martin Jakub ARBET (703 Slovensko, domácí)

Vydání

CIRSE 2016, 2016

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.191

Kód RIV

RIV/00216224:14110/16:00088927

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova česky

ireverzibilní elektroporace; rakjovina žlučových cest; porcinní model

Klíčová slova anglicky

irreversible electroporation; biliary cancer; porcine model

Změněno: 26. 1. 2019 21:04, MUDr. Tomáš Andrašina, Ph.D.

Anotace

V originále

Purpose: To evaluate the safety and efficacy of endoluminal irreversible electroporation (IRE) in biliary tract performed with a balloon catheter in the perihilar region. Material and methods: Endoluminal IRE of the common bile duct was performed in 5 domestic swine using a balloon catheter inserted during laparotomy. IRE catheter consists of 3 electrodes with the length of 1 cm, attached around an inflatable balloon at 120 degrees. IRE was performed with parameters of 50-90 pulses of 1500-2000V delivered between each couple of electrodes. All swine models were slaughtered 3 days after the procedure. Imaging study using MRI and histopathologic follow-up was performed. Results: The balloon insertion and IRE procedure was successful in all porcine models. All animals survived for the designated period of 3 days. Periablation edema in hepatoduodenal ligament and adjacent liver tissue measured on postprocedural MRI ranged from 13 to 40 mm in maximum diameter, 2, 5-18, 7 ml in volumetric assessment. No thrombosis of the portal vein was detected on MRI on days 0 and 3. The elastic membranes of the portal vein were preserved, while endothelial cells were destroyed on histopathologic evaluation. The volume of measured edema increased with energy delivered, in settings with 90 pulses and 2000 V (approx. 2560 V/cm), perforation of common bile duct and hematoma of hepatoduodenal ligament developed in two animals with the highest energy setting (2000 V, 90 pulses). Conclusion: This preliminary study of endoluminal IRE on porcine models demonstrates the feasibility of non-thermal ablation in the perihilar region with a balloon catheter. Higher energy delivered is associated with larger ablation zones but also with higher risk of postprocedural complications.

Návaznosti

NV15-32484A, projekt VaV

Název: Využití nových biotechnologií v prevenci a léčbě stenóz žlučových cest

Citovat

ANDRAŠINA, Tomáš, Jiří PÁNEK, Dalibor ČERVINKA, Iva SVOBODOVÁ a Martin Jakub ARBET. Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results. In CIRSE 2016. 2016. ISSN 0174-1551.

@proceedings{1364975,
   author = {Andrašina, Tomáš and Pánek, Jiří and Červinka, Dalibor and Svobodová, Iva and Arbet, Martin Jakub},
   booktitle = {CIRSE 2016},
   keywords = {irreversible electroporation; biliary cancer; porcine model},
   language = {eng},
   title = {Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results},
   year = {2016}
}

TY  - CONF
ID  - 1364975
AU  - Andrašina, Tomáš - Pánek, Jiří - Červinka, Dalibor - Svobodová, Iva - Arbet, Martin Jakub
PY  - 2016
TI  - Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results
KW  - irreversible electroporation
KW  - biliary cancer
KW  - porcine model
N2  - Purpose: To evaluate the safety and efficacy of endoluminal irreversible electroporation (IRE) in biliary tract performed with a balloon catheter in the perihilar region. Material and methods: Endoluminal IRE of the common bile duct was performed in 5 domestic swine using a balloon catheter inserted during laparotomy. IRE catheter consists of 3 electrodes with the length of 1 cm, attached around an inflatable balloon at 120 degrees. IRE was performed with parameters of 50-90 pulses of 1500-2000V delivered between each couple of electrodes. All swine models were slaughtered 3 days after the procedure. Imaging study using MRI and histopathologic follow-up was performed. Results: The balloon insertion and IRE procedure was successful in all porcine models. All animals survived for the designated period of 3 days. Periablation edema in hepatoduodenal ligament and adjacent liver tissue measured on postprocedural MRI ranged from 13 to 40 mm in maximum diameter, 2, 5-18, 7 ml in volumetric assessment. No thrombosis of the portal vein was detected on MRI on days 0 and 3. The elastic membranes of the portal vein were preserved, while endothelial cells were destroyed on histopathologic evaluation. The volume of measured edema increased with energy delivered, in settings with 90 pulses and 2000 V (approx. 2560 V/cm), perforation of common bile duct and hematoma of hepatoduodenal ligament developed in two animals with the highest energy setting (2000 V, 90 pulses). Conclusion: This preliminary study of endoluminal IRE on porcine models demonstrates the feasibility of non-thermal ablation in the perihilar region with a balloon catheter. Higher energy delivered is associated with larger ablation zones but also with higher risk of postprocedural complications.
ER  -

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