Speech prosody impairment predicts cognitive decline in
Parkinson's disease

J 2016

Speech prosody impairment predicts cognitive decline in Parkinson's disease

REKTOROVÁ, Irena; Jiri MEKYSKA; Eva KORIŤÁKOVÁ; Milena KOŠŤÁLOVÁ; Ilona ELIÁŠOVÁ et. al.

Základní údaje

Originální název

Speech prosody impairment predicts cognitive decline in Parkinson's disease

Autoři

REKTOROVÁ, Irena (203 Česká republika, garant, domácí); Jiri MEKYSKA (203 Česká republika); Eva KORIŤÁKOVÁ (203 Česká republika, domácí); Milena KOŠŤÁLOVÁ (203 Česká republika, domácí); Ilona ELIÁŠOVÁ (203 Česká republika, domácí); Martina MRAČKOVÁ (203 Česká republika, domácí); Dagmar BERÁNKOVÁ (203 Česká republika, domácí); Tereza NEČASOVÁ (203 Česká republika, domácí); Zdenek SMEKAL (203 Česká republika) a Radek MAREČEK (203 Česká republika, domácí)

Vydání

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2016, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.484

Kód RIV

RIV/00216224:14740/16:00088928

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.parkreldis.2016.05.018

UT WoS

000381955700016

EID Scopus

2-s2.0-84969988336

Klíčová slova anglicky

Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia

Štítky

EL OK, podil, rivok

Změněno: 16. 12. 2016 12:52, Mgr. Eva Špillingová

Anotace

V originále

Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NT13499, projekt VaV

Název: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

NV16-30805A, projekt VaV

Název: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí

Přiložené soubory

1364980.pdf

Požádat o autorskou verzi souboru

Citovat

REKTOROVÁ, Irena; Jiri MEKYSKA; Eva KORIŤÁKOVÁ; Milena KOŠŤÁLOVÁ; Ilona ELIÁŠOVÁ; Martina MRAČKOVÁ; Dagmar BERÁNKOVÁ; Tereza NEČASOVÁ; Zdenek SMEKAL a Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2016, roč. 29, August, s. 90-95. ISSN 1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018.

@article{1364980,
   author = {Rektorová, Irena and Mekyska, Jiri and Koriťáková, Eva and Košťálová, Milena and Eliášová, Ilona and Mračková, Martina and Beránková, Dagmar and Nečasová, Tereza and Smekal, Zdenek and Mareček, Radek},
   article_location = {OXFORD},
   article_number = {August},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2016.05.018},
   keywords = {Parkinson's disease; Speech prosody; Acoustic analysis; Cognitive; Dementia},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Speech prosody impairment predicts cognitive decline in Parkinson's disease},
   url = {http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278},
   volume = {29},
   year = {2016}
}

TY  - JOUR
ID  - 1364980
AU  - Rektorová, Irena - Mekyska, Jiri - Koriťáková, Eva - Košťálová, Milena - Eliášová, Ilona - Mračková, Martina - Beránková, Dagmar - Nečasová, Tereza - Smekal, Zdenek - Mareček, Radek
PY  - 2016
TI  - Speech prosody impairment predicts cognitive decline in Parkinson's disease
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 29
IS  - August
SP  - 90-95
EP  - 90-95
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Parkinson's disease
KW  - Speech prosody
KW  - Acoustic analysis
KW  - Cognitive
KW  - Dementia
UR  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
L2  - http://ac.els-cdn.com/S1353802016301705/1-s2.0-S1353802016301705-main.pdf?_tid=788e4f5c-c2a7-11e6-b780-00000aacb362&acdnat=1481793702_a0f60c8ee72ca0836953a9099a5fb278
N2  - Background: Impairment of speech prosody is characteristic for Parkinson's disease (PD) and does not respond well to dopaminergic treatment. Objectives: We assessed whether baseline acoustic parameters, alone or in combination with other predominantly non-dopaminergic symptoms may predict global cognitive decline as measured by the Addenbrooke's cognitive examination (ACE-R) and/or worsening of cognitive status as assessed by a detailed neuropsychological examination. Methods: Forty-four consecutive non-depressed PD patients underwent clinical and cognitive testing, and acoustic voice analysis at baseline and at the two-year follow-up. Influence of speech and other clinical parameters on worsening of the ACE-R and of the cognitive status was analyzed using linear and logistic regression. Results: The cognitive status (classified as normal cognition, mild cognitive impairment and dementia) deteriorated in 25% of patients during the follow-up. The multivariate linear regression model consisted of the variation in range of the fundamental voice frequency (F0VR) and the REM Sleep Behavioral Disorder Screening Questionnaire (RBDSQ). These parameters explained 37.2% of the variability of the change in ACE-R. The most significant predictors in the univariate logistic regression were the speech index of rhythmicity (SPIR; p = 0.012), disease duration (p = 0.019), and the RBDSQ (p = 0.032). The multivariate regression analysis revealed that SPIR alone led to 73.2% accuracy in predicting a change in cognitive status. Combining SPIR with RBDSQ improved the prediction accuracy of SPIR alone by 73%. Conclusions: Impairment of speech prosody together with symptoms of RBD predicted rapid cognitive decline and worsening of PD cognitive status during a two-year period. (C) 2016 Elsevier Ltd. All rights reserved.
ER  -

REKTOROVÁ, Irena; Jiri MEKYSKA; Eva KORIŤÁKOVÁ; Milena KOŠŤÁLOVÁ; Ilona ELIÁŠOVÁ; Martina MRAČKOVÁ; Dagmar BERÁNKOVÁ; Tereza NEČASOVÁ; Zdenek SMEKAL a Radek MAREČEK. Speech prosody impairment predicts cognitive decline in Parkinson's disease. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, roč.~29, August, s.~90-95. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2016.05.018.

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