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@article{1366449,
author = {Mach, Lukáš and Bedáňová, Helena and Souček, Miroslav and Karpisek, Michal and Němec, Petr and Orban, Marek},
article_location = {Clare},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.022},
keywords = {Coronary artery disease; Cytokines; Epicardial adipose tissue; Inflammation; Smoking},
language = {eng},
issn = {0021-9150},
journal = {Atherosclerosis},
title = {Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation},
volume = {255},
year = {2016}
}
TY - JOUR
ID - 1366449
AU - Mach, Lukáš - Bedáňová, Helena - Souček, Miroslav - Karpisek, Michal - Němec, Petr - Orban, Marek
PY - 2016
TI - Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation
JF - Atherosclerosis
VL - 255
IS - "neuvedeno"
SP - 37-42
EP - 37-42
PB - Elsevier Ireland Ltd.
SN - 00219150
KW - Coronary artery disease
KW - Cytokines
KW - Epicardial adipose tissue
KW - Inflammation
KW - Smoking
N2 - Background and aims Epicardial adipose tissue (EAT) is a source of a number of cytokines which could act in the pathogenesis of coronary artery disease (CAD). The potential relationship between known cardiovascular risk factors, such as smoking, dyslipidaemia or diabetes mellitus and EAT humoral signalling, has not been fully elucidated. Therefore, we designed and conducted a cross-sectional study to determine whether selected cardiovascular risk factors are linked to levels of cytokines in epicardial and subcutaneous adipose tissue (SAT). Methods Samples of SAT and EAT were collected from consecutive patients undergoing scheduled cardiac surgery. Tissue concentrations of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adipocyte fatty acid-binding protein, leptin, and adiponectin were determined by ELISA. Results We enrolled 140 patients. TNF-alpha and IL-6 concentrations in EAT and SAT were significantly higher in current smokers (CS) than in never smokers (NS) and former smokers (FS). There were no differences between FS and NS. No other clinical variables were associated with cytokine concentrations in a regression analysis. Conclusions Smoking was independently associated with higher TNF-alpha and IL-6 concentrations in EAT and SAT. A novel observation that pro-inflammatory cytokines are elevated in EAT in smokers could contribute to identify potential mechanisms involved in the pathogenesis of adverse effects of tobacco smoking. There were no differences between EAT cytokine production in NS and FS, which support the importance of smoking cessation for cardiovascular risk reduction.
ER -
MACH, Lukáš, Helena BEDÁŇOVÁ, Miroslav SOUČEK, Michal KARPISEK, Petr NĚMEC a Marek ORBAN. Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation. \textit{Atherosclerosis}. Clare: Elsevier Ireland Ltd., 2016, roč.~255, ''neuvedeno'', s.~37-42. ISSN~0021-9150. Dostupné z: https://dx.doi.org/10.1016/j.atherosclerosis.2016.10.022.
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