MACH, Lukáš, Helena BEDÁŇOVÁ, Miroslav SOUČEK, Michal KARPISEK, Petr NĚMEC a Marek ORBAN. Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation. Atherosclerosis. Clare: Elsevier Ireland Ltd., 2016, roč. 255, "neuvedeno", s. 37-42. ISSN 0021-9150. Dostupné z: https://dx.doi.org/10.1016/j.atherosclerosis.2016.10.022.
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Základní údaje
Originální název Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation
Autoři MACH, Lukáš (203 Česká republika, domácí), Helena BEDÁŇOVÁ (203 Česká republika, domácí), Miroslav SOUČEK (203 Česká republika, domácí), Michal KARPISEK (203 Česká republika), Petr NĚMEC (203 Česká republika) a Marek ORBAN (203 Česká republika, garant).
Vydání Atherosclerosis, Clare, Elsevier Ireland Ltd. 2016, 0021-9150.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Irsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 4.239
Kód RIV RIV/00216224:14110/16:00092632
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.022
UT WoS 000389509700030
Klíčová slova anglicky Coronary artery disease; Cytokines; Epicardial adipose tissue; Inflammation; Smoking
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 26. 4. 2017 12:38.
Anotace
Background and aims Epicardial adipose tissue (EAT) is a source of a number of cytokines which could act in the pathogenesis of coronary artery disease (CAD). The potential relationship between known cardiovascular risk factors, such as smoking, dyslipidaemia or diabetes mellitus and EAT humoral signalling, has not been fully elucidated. Therefore, we designed and conducted a cross-sectional study to determine whether selected cardiovascular risk factors are linked to levels of cytokines in epicardial and subcutaneous adipose tissue (SAT). Methods Samples of SAT and EAT were collected from consecutive patients undergoing scheduled cardiac surgery. Tissue concentrations of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adipocyte fatty acid-binding protein, leptin, and adiponectin were determined by ELISA. Results We enrolled 140 patients. TNF-alpha and IL-6 concentrations in EAT and SAT were significantly higher in current smokers (CS) than in never smokers (NS) and former smokers (FS). There were no differences between FS and NS. No other clinical variables were associated with cytokine concentrations in a regression analysis. Conclusions Smoking was independently associated with higher TNF-alpha and IL-6 concentrations in EAT and SAT. A novel observation that pro-inflammatory cytokines are elevated in EAT in smokers could contribute to identify potential mechanisms involved in the pathogenesis of adverse effects of tobacco smoking. There were no differences between EAT cytokine production in NS and FS, which support the importance of smoking cessation for cardiovascular risk reduction.
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