Frequency-independent characteristics of high-frequency
oscillations in epileptic and non-epileptic regions

J 2017

Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions

PAIL, Martin, Pavel ŘEHULKA, Jan CIMBÁLNÍK, Irena DOLEŽALOVÁ, Jan CHRASTINA et. al.

Základní údaje

Originální název

Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions

Autoři

PAIL, Martin (203 Česká republika, garant, domácí), Pavel ŘEHULKA (203 Česká republika), Jan CIMBÁLNÍK (203 Česká republika), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Jan CHRASTINA (203 Česká republika) a Milan BRÁZDIL (203 Česká republika, domácí)

Vydání

Clinical Neurophysiology, Clare, Elsevier Ireland Ltd. 2017, 1388-2457

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.614

Kód RIV

RIV/00216224:14110/17:00094601

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.clinph.2016.10.011

UT WoS

000396377300011

Klíčová slova anglicky

Epileptogenic zone; Extratemporal lobe epilepsy; Fast ripples; High frequency oscillations; Irritative zone; Ripples; Seizure onset zone; Temporal lobe epilepsy

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 18:17, Soňa Böhmová

Anotace

V originále

Objective The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions. Methods We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ). Results In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes. Conclusions FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ. Significance Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP103/11/0933, projekt VaV

Název: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Investor: Grantová agentura ČR, Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

PAIL, Martin, Pavel ŘEHULKA, Jan CIMBÁLNÍK, Irena DOLEŽALOVÁ, Jan CHRASTINA a Milan BRÁZDIL. Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions. Clinical Neurophysiology. Clare: Elsevier Ireland Ltd., 2017, roč. 128, č. 1, s. 106-114. ISSN 1388-2457. Dostupné z: https://dx.doi.org/10.1016/j.clinph.2016.10.011.

@article{1367295,
   author = {Pail, Martin and Řehulka, Pavel and Cimbálník, Jan and Doležalová, Irena and Chrastina, Jan and Brázdil, Milan},
   article_location = {Clare},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.clinph.2016.10.011},
   keywords = {Epileptogenic zone; Extratemporal lobe epilepsy; Fast ripples; High frequency oscillations; Irritative zone; Ripples; Seizure onset zone; Temporal lobe epilepsy},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions},
   volume = {128},
   year = {2017}
}

TY  - JOUR
ID  - 1367295
AU  - Pail, Martin - Řehulka, Pavel - Cimbálník, Jan - Doležalová, Irena - Chrastina, Jan - Brázdil, Milan
PY  - 2017
TI  - Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions
JF  - Clinical Neurophysiology
VL  - 128
IS  - 1
SP  - 106-114
EP  - 106-114
PB  - Elsevier Ireland Ltd.
SN  - 13882457
KW  - Epileptogenic zone
KW  - Extratemporal lobe epilepsy
KW  - Fast ripples
KW  - High frequency oscillations
KW  - Irritative zone
KW  - Ripples
KW  - Seizure onset zone
KW  - Temporal lobe epilepsy
N2  - Objective The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions. Methods We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ). Results In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes. Conclusions FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ. Significance Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity.
ER  -

PAIL, Martin, Pavel ŘEHULKA, Jan CIMBÁLNÍK, Irena DOLEŽALOVÁ, Jan CHRASTINA a Milan BRÁZDIL. Frequency-independent characteristics of high-frequency oscillations in epileptic and non-epileptic regions. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland Ltd., 2017, roč.~128, č.~1, s.~106-114. ISSN~1388-2457. Dostupné z: https://dx.doi.org/10.1016/j.clinph.2016.10.011.

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