Tri- and tetravalent mannoclusters cross-link and aggregate
BC2L-A lectin from Burkholderia cenocepacia

J 2017

Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia

CSÁVÁS, Magdolna; Lenka MALINOVSKÁ; Florent PERRET; Milán GYURKÓ; Zita Tünde ILLYÉS et al.

Základní údaje

Originální název

Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia

Autoři

CSÁVÁS, Magdolna; Lenka MALINOVSKÁ ; Florent PERRET; Milán GYURKÓ; Zita Tünde ILLYÉS; Michaela WIMMEROVÁ a Anikó BORBÁS

Vydání

Carbohydrate Research, Elsevier Science, 2017, 0008-6215

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.074

Kód RIV

RIV/00216224:14740/17:00094607

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1016/j.carres.2016.11.008

UT WoS

000392557900001

EID Scopus

2-s2.0-84997294366

Klíčová slova anglicky

Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy

Štítky

CF BIC

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 3. 2018 15:27, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation.

Návaznosti

GA15-17572S, projekt VaV

Název: Glykoklastry kalix[4]aren/C-oligosacharidy pro studium selektivity interakcí s lektiny

Investor: Grantová agentura ČR, Glykoklastry kalix[4]aren/C-oligosacharidy pro studium selektivity interakcí s lektiny

LM2015043, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

Citovat

CSÁVÁS, Magdolna; Lenka MALINOVSKÁ; Florent PERRET; Milán GYURKÓ; Zita Tünde ILLYÉS; Michaela WIMMEROVÁ a Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. Carbohydrate Research. Elsevier Science, 2017, roč. 437, January 2017, s. 1-8. ISSN 0008-6215. Dostupné z: https://doi.org/10.1016/j.carres.2016.11.008.

@article{1368358,
   author = {Csávás, Magdolna and Malinovská, Lenka and Perret, Florent and Gyurkó, Milán and Illyés, Zita Tünde and Wimmerová, Michaela and Borbás, Anikó},
   article_number = {January 2017},
   doi = {https://doi.org/10.1016/j.carres.2016.11.008},
   keywords = {Burkholderia cenocepacia; Mannose-binding lectin; Glycoclusters; Click reaction; Anti-adhesion therapy},
   language = {eng},
   issn = {0008-6215},
   journal = {Carbohydrate Research},
   title = {Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia},
   url = {https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub},
   volume = {437},
   year = {2017}
}

TY  - JOUR
ID  - 1368358
AU  - Csávás, Magdolna - Malinovská, Lenka - Perret, Florent - Gyurkó, Milán - Illyés, Zita Tünde - Wimmerová, Michaela - Borbás, Anikó
PY  - 2017
TI  - Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia
JF  - Carbohydrate Research
VL  - 437
IS  - January 2017
SP  - 1-8
EP  - 1-8
PB  - Elsevier Science
SN  - 00086215
KW  - Burkholderia cenocepacia
KW  - Mannose-binding lectin
KW  - Glycoclusters
KW  - Click reaction
KW  - Anti-adhesion therapy
UR  - https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0008621516303160?via%3Dihub
N2  - The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. The interaction between the glycoclusters and the mannose binding BC2L-A lectin from B. cenocepacia was examined by isothermal microcalorimetry, surface plasmon resonance, inhibition of yeast agglutination and analytical ultracentrifugation.
ER  -

CSÁVÁS, Magdolna; Lenka MALINOVSKÁ; Florent PERRET; Milán GYURKÓ; Zita Tünde ILLYÉS; Michaela WIMMEROVÁ a Anikó BORBÁS. Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia. \textit{Carbohydrate Research}. Elsevier Science, 2017, roč.~437, January 2017, s.~1-8. ISSN~0008-6215. Dostupné z: https://doi.org/10.1016/j.carres.2016.11.008.

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