2017
Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia
VÝTVAROVÁ, Eva, Radek MAREČEK, Jan FOUSEK, Ondřej STRÝČEK, Ivan REKTOR et. al.Základní údaje
Originální název
Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia
Autoři
VÝTVAROVÁ, Eva (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Jan FOUSEK (203 Česká republika, domácí), Ondřej STRÝČEK (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)
Vydání
NeuroImage-Clinical, Oxford, Elsevier BV, 2017, 2213-1582
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30103 Neurosciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 3.869
Kód RIV
RIV/00216224:14740/17:00094611
Organizační jednotka
Středoevropský technologický institut
UT WoS
000405984300003
Klíčová slova anglicky
Functional magnetic resonance imaging; Functional connectivity; Epilepsy; Network analysis; Partial least square analysis
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 26. 4. 2018 12:49, Mgr. Pavla Foltynová, Ph.D.
Anotace
V originále
Objectives: The aimwas to describe the contribution of basal ganglia (BG) thalamo-cortical circuitry to thewholebrain functional connectivity in focal epilepsies. Methods: Interictal resting-state fMRI recordings were acquired in 46 persons with focal epilepsies. Of these 46, 22 had temporal lobe epilepsy: 9 left temporal (LTLE), 13 right temporal (RTLE); 15 had frontal lobe epilepsy (FLE); and 9 had parietal/ occipital lobe epilepsy (POLE). There were 20 healthy controls. The completeweighted networkwas analyzed based on correlation matrices of 90 and 194 regions. The network topologywas quantified on a global and regional level by measures based on graph theory, and connection-level changes were analyzed by the partial least square method. Results: In all patient groups except RTLE, the shift of the functional network topology away from random was observed (normalized clustering coefficient and characteristic path length were higher in patient groups than in controls). Links contributing to this change were found in the cortico-subcortical connections. Weak connections (low correlations) consistently contributed to thismodification of the network. The importance of regions changed: decreases in the subcortical areas and both decreases and increases in the cortical areas were observed in node strength, clustering coefficient and eigenvector centrality in patient groups when compared to controls. Node strength decreases of the basal ganglia, i.e. the putamen, caudate, and pallidum, were displayed in LTLE, FLE, and POLE. The connectivity within the basal ganglia-thalamus circuitry was not disturbed; the disturbance concerned the connectivity between the circuitry and the cortex. Significance: Focal epilepsies affect large-scale brain networks beyond the epileptogenic zones. Cortico-subcortical functional connectivity disturbance was displayed in LTLE, FLE, and POLE. Significant changes in the restingstate functional connectivity between cortical and subcortical structures suggest an important role of the BG and thalamus in focal epilepsies.
Návaznosti
| GAP103/11/0933, projekt VaV |
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| LM2010005, projekt VaV |
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| LQ1601, projekt VaV |
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| MUNI/A/0897/2016, interní kód MU |
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| MUNI/A/0945/2015, interní kód MU |
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