Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric
Dimethylarginine-Induced Pulmonary Endothelial Dysfunction

J 2016

Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction

KOUDELKA, Adolf, Gabriela AMBROŽOVÁ, Anna KLINKE, Táňa FIDLEROVÁ, Hana VEREŠČÁKOVÁ et. al.

Basic information

Original name

Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction

Authors

KOUDELKA, Adolf (203 Czech Republic), Gabriela AMBROŽOVÁ (203 Czech Republic), Anna KLINKE, Táňa FIDLEROVÁ (203 Czech Republic, belonging to the institution), Hana VEREŠČÁKOVÁ (203 Czech Republic, belonging to the institution), Radek KUCHTA, Tanja K RUDOLPH, Jaroslav KADLEC, Zdenka KUCHTOVA, Steven R. WOODCOCK, Bruce A. FREEMAN, Lukáš KUBALA (203 Czech Republic) and Michaela PEKAROVÁ (703 Slovakia, guarantor)

Edition

Cardiovascular Drugs and Therapy, Springer, 2016, 0920-3206

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.820

RIV identification code

RIV/00216224:14310/16:00114974

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s10557-016-6700-3

UT WoS

000390066300005

Keywords in English

Nitro-oleic acid; Asymmetric dimethylarginine; Hypoxia; Pulmonary hypertension; Human pulmonary artery endothelial cell

Abstract

V originále

Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.

Citovat

KOUDELKA, Adolf, Gabriela AMBROŽOVÁ, Anna KLINKE, Táňa FIDLEROVÁ, Hana VEREŠČÁKOVÁ, Radek KUCHTA, Tanja K RUDOLPH, Jaroslav KADLEC, Zdenka KUCHTOVA, Steven R. WOODCOCK, Bruce A. FREEMAN, Lukáš KUBALA and Michaela PEKAROVÁ. Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction. Cardiovascular Drugs and Therapy. Springer, 2016, vol. 30, No 6, p. 579-586. ISSN 0920-3206. Available from: https://dx.doi.org/10.1007/s10557-016-6700-3.

@article{1368562,
   author = {Koudelka, Adolf and Ambrožová, Gabriela and Klinke, Anna and Fidlerová, Táňa and Vereščáková, Hana and Kuchta, Radek and Rudolph, Tanja K and Kadlec, Jaroslav and Kuchtova, Zdenka and Woodcock, Steven R. and Freeman, Bruce A. and Kubala, Lukáš and Pekarová, Michaela},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s10557-016-6700-3},
   keywords = {Nitro-oleic acid; Asymmetric dimethylarginine; Hypoxia; Pulmonary hypertension; Human pulmonary artery endothelial cell},
   language = {eng},
   issn = {0920-3206},
   journal = {Cardiovascular Drugs and Therapy},
   title = {Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction},
   url = {http://link.springer.com/article/10.1007/s10557-016-6700-3},
   volume = {30},
   year = {2016}
}

TY  - JOUR
ID  - 1368562
AU  - Koudelka, Adolf - Ambrožová, Gabriela - Klinke, Anna - Fidlerová, Táňa - Vereščáková, Hana - Kuchta, Radek - Rudolph, Tanja K - Kadlec, Jaroslav - Kuchtova, Zdenka - Woodcock, Steven R. - Freeman, Bruce A. - Kubala, Lukáš - Pekarová, Michaela
PY  - 2016
TI  - Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction
JF  - Cardiovascular Drugs and Therapy
VL  - 30
IS  - 6
SP  - 579-586
EP  - 579-586
PB  - Springer
SN  - 09203206
KW  - Nitro-oleic acid
KW  - Asymmetric dimethylarginine
KW  - Hypoxia
KW  - Pulmonary hypertension
KW  - Human pulmonary artery endothelial cell
UR  - http://link.springer.com/article/10.1007/s10557-016-6700-3
L2  - http://link.springer.com/article/10.1007/s10557-016-6700-3
N2  - Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.
ER  -

KOUDELKA, Adolf, Gabriela AMBROŽOVÁ, Anna KLINKE, Táňa FIDLEROVÁ, Hana VEREŠČÁKOVÁ, Radek KUCHTA, Tanja K RUDOLPH, Jaroslav KADLEC, Zdenka KUCHTOVA, Steven R. WOODCOCK, Bruce A. FREEMAN, Lukáš KUBALA and Michaela PEKAROVÁ. Nitro-Oleic Acid Prevents Hypoxia-and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction. \textit{Cardiovascular Drugs and Therapy}. Springer, 2016, vol.~30, No~6, p.~579-586. ISSN~0920-3206. Available from: https://dx.doi.org/10.1007/s10557-016-6700-3.

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