2016
Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption
VALÍKOVÁ, Petra, Petra BOŘILOVÁ LINHARTOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, M. MRKVICOVA et. al.Základní údaje
Originální název
Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption
Autoři
VALÍKOVÁ, Petra (203 Česká republika, garant, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí), Pavlína ČERNOCHOVÁ (203 Česká republika, domácí) a M. MRKVICOVA (203 Česká republika)
Vydání
92nd Congress of the European Orthodontic Society, Stockholm, 2016
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Švédsko
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/16:00088649
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
vitamin D
Štítky
Změněno: 8. 2. 2017 15:48, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
AIMS: To investigate possible links between single nucleotid polymorphisms in vitamin D receptor gene and root resorption after orthodontic treatment. SUBJECTS AND METHOD: One hundred children were included in this study (31 patients aged 10 ± 4.1 years with external apical root resorption greater than 2 mm on panoramic radiographs after orthodontic treatment and 69 patients aged 12 ± 3 years without resorption). DNA was analyzed with real-time polymerase chain reaction for TaqI, BsmI, ApaI, FokI and Cdx2 polymorphisms. The obtained genotypes were evaluated in relation to gender, age, skeletal Class and the type of orthodontic treatment. RESULTS: No statistically significant differences were found between patients with and without resorption concerning occurrence of alleles or genotypes for each polymorphism. In a more detailed analysis, marginally important differences (trends) were observed for the frequencies of ApaI (P = 0.059) and the haplotype TGCTA (P = 0.063) in boys. CONCLUSION: Even though a significant role of vitamin D receptor gene polymorphisms was not established in girls, more research is needed in boys. In this small cohort of patients no associations of vitamin D receptor polymorphisms in girls were observed. In boys more research in needed as the slight trends observed imply possible associations of vitamin D polymorphisms with external apical root resorption.
Návaznosti
GB14-37368G, projekt VaV |
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MUNI/A/1359/2014, interní kód MU |
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NT11420, projekt VaV |
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