Redox Processes of Guanine Moieties in DNA Heptamers Related to
Hydrogen Evolution

J 2016

Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

TŘÍSKOVÁ, Iveta, Radovan FIALA a Libuše TRNKOVÁ

Základní údaje

Originální název

Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution

Autoři

TŘÍSKOVÁ, Iveta (203 Česká republika, domácí), Radovan FIALA (203 Česká republika, domácí) a Libuše TRNKOVÁ (203 Česká republika, garant, domácí)

Vydání

Electroanalysis, 2016, 1040-0397

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.851

Kód RIV

RIV/00216224:14310/16:00093647

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/elan.201600321

UT WoS

000387891400028

Klíčová slova česky

vlásenky; NMR DNA heptamerů; cyklická voltametrie; vylučování vodíku; potenciál bodu obratu; neurodegenerativní onemocnění

Klíčová slova anglicky

Hairpins; NMR of DNA heptamers; cyclic voltammetry; hydrogen evolution reaction; vertex potential; neurodegenerative diseases

Štítky

AKR, rivok

Změněno: 23. 4. 2020 17:37, Mgr. Marie Šípková, DiS.

Anotace

V originále

The paper is focused on the electrochemical investigation of DNA heptamers d(GCXXXGC) with different central triplets of nucleotides (XXX=GAA, AAA, CCC, GGG). On a hanging mercury electrode (HMDE), the reduction peaks of adenine (A) and cytosine (C) moieties are detectable, but those of guanine (G) moieties are covered by an intensive current of hydrogen evolution. Because cyclic voltammetry allows us to monitor only the oxidation processes of the G reduced species, the effect of hydrogen evolution reaction (HER) was studied by means of these anodic signals. For different vertex potentials (from -1.60V to -1.85V) and a different number of cycles (1-5), all heptamers in buffered solutions (pH5.8) were tested and double-peak G oxidation signals (GI and GII) evaluated. The different structures of the heptamers in solutions are confirmed by NMR spectra. Both the impact of hydrogen evolution into the production of 7,8-dihydroguanine moieties forming together with hydrogen in negative potentials and the catalytic effect of heptamers on hydrogen evolution are discussed.

Citovat

TŘÍSKOVÁ, Iveta, Radovan FIALA a Libuše TRNKOVÁ. Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution. Electroanalysis. 2016, roč. 28, č. 11, s. 2841-2848. ISSN 1040-0397. Dostupné z: https://dx.doi.org/10.1002/elan.201600321.

@article{1373345,
   author = {Třísková, Iveta and Fiala, Radovan and Trnková, Libuše},
   article_number = {11},
   doi = {http://dx.doi.org/10.1002/elan.201600321},
   keywords = {Hairpins; NMR of DNA heptamers; cyclic voltammetry; hydrogen evolution reaction; vertex potential; neurodegenerative diseases},
   language = {eng},
   issn = {1040-0397},
   journal = {Electroanalysis},
   title = {Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full},
   volume = {28},
   year = {2016}
}

TY  - JOUR
ID  - 1373345
AU  - Třísková, Iveta - Fiala, Radovan - Trnková, Libuše
PY  - 2016
TI  - Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution
JF  - Electroanalysis
VL  - 28
IS  - 11
SP  - 2841-2848
EP  - 2841-2848
SN  - 10400397
KW  - Hairpins
KW  - NMR of DNA heptamers
KW  - cyclic voltammetry
KW  - hydrogen evolution reaction
KW  - vertex potential
KW  - neurodegenerative diseases
UR  - http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full
L2  - http://onlinelibrary.wiley.com/doi/10.1002/elan.201600321/full
N2  - The paper is focused on the electrochemical investigation of DNA heptamers d(GCXXXGC) with different central triplets of nucleotides (XXX=GAA, AAA, CCC, GGG). On a hanging mercury electrode (HMDE), the reduction peaks of adenine (A) and cytosine (C) moieties are detectable, but those of guanine (G) moieties are covered by an intensive current of hydrogen evolution. Because cyclic voltammetry allows us to monitor only the oxidation processes of the G reduced species, the effect of hydrogen evolution reaction (HER) was studied by means of these anodic signals. For different vertex potentials (from -1.60V to -1.85V) and a different number of cycles (1-5), all heptamers in buffered solutions (pH5.8) were tested and double-peak G oxidation signals (GI and GII) evaluated. The different structures of the heptamers in solutions are confirmed by NMR spectra. Both the impact of hydrogen evolution into the production of 7,8-dihydroguanine moieties forming together with hydrogen in negative potentials and the catalytic effect of heptamers on hydrogen evolution are discussed.
ER  -

TŘÍSKOVÁ, Iveta, Radovan FIALA a Libuše TRNKOVÁ. Redox Processes of Guanine Moieties in DNA Heptamers Related to Hydrogen Evolution. \textit{Electroanalysis}. 2016, roč.~28, č.~11, s.~2841-2848. ISSN~1040-0397. Dostupné z: https://dx.doi.org/10.1002/elan.201600321.

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