Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA
macromonomers terminated by alpha,omega-itaconyl groups

J 2016

Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups

MICHLOVSKA, L., L. VOJTOVA, Otakar HUMPA, J. KUCERIK, J. ZIDEK et. al.

Základní údaje

Originální název

Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups

Autoři

MICHLOVSKA, L. (203 Česká republika), L. VOJTOVA (203 Česká republika), Otakar HUMPA (203 Česká republika, garant, domácí), J. KUCERIK (276 Německo), J. ZIDEK (203 Česká republika) a J. JANCAR (203 Česká republika)

Vydání

RSC Advances, Cambridge, Royal Society of Chemistry, 2016, 2046-2069

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.108

Kód RIV

RIV/00216224:14740/16:00093660

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1039/c5ra26222d

UT WoS

000370710600090

Klíčová slova anglicky

ITACONIC ANHYDRIDE; COPOLYMERS; METHACRYLATE; COMPOSITES; OLIGOMERS; POLYMERS; DELIVERY; LACTIDE

Štítky

rivok

Změněno: 23. 2. 2017 14:23, Mgr. Eva Špillingová

Anotace

V originále

Biodegradable amphiphilic PLGA-PEG-PLGA triblock copolymers end-terminated with itaconic acid (ITA) having reactive double bonds were synthesized by ring opening polymerization. The prepared alpha,omega-itaconyl-PLGA- PEG-PLGA telechelic macromonomers were additionally covalently crosslinked under an inert atmosphere by blue light irradiation without the use of a further cross-linker resulting in end-linked polymeric networks. The effects of the ITA amount attached to the alpha,omega-itaconyl-PLGA-PEG-PLGA copolymers and the crosslinking time on swelling behaviours and hydrolytic stability of the prepared well-defined polymeric network were investigated. Physicochemical properties were characterized by proton and carbon nuclear magnetic resonance spectroscopy (H-1 NMR, C-13 NMR), proton nuclear magnetic resonance relaxometry, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). It was found that the hydrolytic stability of ITA modified PLGA-PEG-PLGA end-linked hydrogels enhances with both increasing the time of crosslinking and the amount of double bonds attached to alpha,omega-itaconyl-PLGA-PEG-PLGA polymer chains. In comparison with the original un-crosslinked alpha,omega-itaconyl-PLGA-PEG-PLGA copolymer, the hydrolytic stability of the end-linked hydrogels significantly increased. Three kinds of water fractions (unbound, weakly and strongly bonded) were determined by proton NMR relaxometry in hydrogels containing 63 mol% of ITA crosslinked for 40 minutes. Even for hydrogels surviving 32 days in water the NMR relaxometry showed structural collapse of the hydrogel probably due to breaking of end-linked nodes followed by hydrolysis faster than water diffusion after day 15 of immersion. End-linked alpha,omega-itaconyl-PLGA- PEG-PLGA hydrogels can be used in medical, biological or tissue engineering applications.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

MICHLOVSKA, L., L. VOJTOVA, Otakar HUMPA, J. KUCERIK, J. ZIDEK a J. JANCAR. Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups. RSC Advances. Cambridge: Royal Society of Chemistry, 2016, roč. 6, č. 20, s. 16808-16816. ISSN 2046-2069. Dostupné z: https://dx.doi.org/10.1039/c5ra26222d.

@article{1373371,
   author = {Michlovska, L. and Vojtova, L. and Humpa, Otakar and Kucerik, J. and Zidek, J. and Jancar, J.},
   article_location = {Cambridge},
   article_number = {20},
   doi = {http://dx.doi.org/10.1039/c5ra26222d},
   keywords = {ITACONIC ANHYDRIDE; COPOLYMERS; METHACRYLATE; COMPOSITES; OLIGOMERS; POLYMERS; DELIVERY; LACTIDE},
   language = {eng},
   issn = {2046-2069},
   journal = {RSC Advances},
   title = {Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups},
   url = {http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1373371
AU  - Michlovska, L. - Vojtova, L. - Humpa, Otakar - Kucerik, J. - Zidek, J. - Jancar, J.
PY  - 2016
TI  - Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups
JF  - RSC Advances
VL  - 6
IS  - 20
SP  - 16808-16816
EP  - 16808-16816
PB  - Royal Society of Chemistry
SN  - 20462069
KW  - ITACONIC ANHYDRIDE
KW  - COPOLYMERS
KW  - METHACRYLATE
KW  - COMPOSITES
KW  - OLIGOMERS
KW  - POLYMERS
KW  - DELIVERY
KW  - LACTIDE
UR  - http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract
L2  - http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA26222D#!divAbstract
N2  - Biodegradable amphiphilic PLGA-PEG-PLGA triblock copolymers end-terminated with itaconic acid (ITA) having reactive double bonds were synthesized by ring opening polymerization. The prepared alpha,omega-itaconyl-PLGA- PEG-PLGA telechelic macromonomers were additionally covalently crosslinked under an inert atmosphere by blue light irradiation without the use of a further cross-linker resulting in end-linked polymeric networks. The effects of the ITA amount attached to the alpha,omega-itaconyl-PLGA-PEG-PLGA copolymers and the crosslinking time on swelling behaviours and hydrolytic stability of the prepared well-defined polymeric network were investigated. Physicochemical properties were characterized by proton and carbon nuclear magnetic resonance spectroscopy (H-1 NMR, C-13 NMR), proton nuclear magnetic resonance relaxometry, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). It was found that the hydrolytic stability of ITA modified PLGA-PEG-PLGA end-linked hydrogels enhances with both increasing the time of crosslinking and the amount of double bonds attached to alpha,omega-itaconyl-PLGA-PEG-PLGA polymer chains. In comparison with the original un-crosslinked alpha,omega-itaconyl-PLGA-PEG-PLGA copolymer, the hydrolytic stability of the end-linked hydrogels significantly increased. Three kinds of water fractions (unbound, weakly and strongly bonded) were determined by proton NMR relaxometry in hydrogels containing 63 mol% of ITA crosslinked for 40 minutes. Even for hydrogels surviving 32 days in water the NMR relaxometry showed structural collapse of the hydrogel probably due to breaking of end-linked nodes followed by hydrolysis faster than water diffusion after day 15 of immersion. End-linked alpha,omega-itaconyl-PLGA- PEG-PLGA hydrogels can be used in medical, biological or tissue engineering applications.
ER  -

MICHLOVSKA, L., L. VOJTOVA, Otakar HUMPA, J. KUCERIK, J. ZIDEK a J. JANCAR. Hydrolytic stability of end-linked hydrogels from PLGA-PEG-PLGA macromonomers terminated by alpha,omega-itaconyl groups. \textit{RSC Advances}. Cambridge: Royal Society of Chemistry, 2016, roč.~6, č.~20, s.~16808-16816. ISSN~2046-2069. Dostupné z: https://dx.doi.org/10.1039/c5ra26222d.

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