TWISTED DWARF1 Mediates the Action of Auxin Transport
Inhibitors on Actin Cytoskeleton Dynamics

J 2016

TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics

ZHU, Jinsheng; Aurelie BAILLY; Marta ZWIEWKA; Valpuri SOVERO; Martin DI DONATO et al.

Základní údaje

Originální název

TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics

Autoři

Vydání

Plant Cell, ROCKVILLE, AMER SOC PLANT BIOLOGISTS, 2016, 1040-4651

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.726

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/16:00088716

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

ACID-BINDING PROTEIN; ARABIDOPSIS-THALIANA; PLASMA-MEMBRANE; PLANT DEVELOPMENT; ABC TRANSPORTERS; P-GLYCOPROTEINS; CORTICAL ARRAY; INTRACELLULAR TRAFFICKING; FUNCTIONALLY INTERACTS; EFFLUX TRANSPORTER

Štítky

rivok

Změněno: 27. 2. 2017 15:04, Mgr. Eva Špillingová

Anotace

V originále

Plant growth and architecture is regulated by the polar distribution of the hormone auxin. Polarity and flexibility of this process is provided by constant cycling of auxin transporter vesicles along actin filaments, coordinated by a positive auxin-actin feedback loop. Both polar auxin transport and vesicle cycling are inhibited by synthetic auxin transport inhibitors, such as 1-N-naphthylphthalamic acid (NPA), counteracting the effect of auxin; however, underlying targets and mechanisms are unclear. Using NMR, we map the NPA binding surface on the Arabidopsis thaliana ABCB chaperone TWISTED DWARF1 (TWD1). We identify ACTIN7 as a relevant, although likely indirect, TWD1 interactor, and show TWD1-dependent regulation of actin filament organization and dynamics and that TWD1 is required for NPA-mediated actin cytoskeleton remodeling. The TWD1-ACTIN7 axis controls plasma membrane presence of efflux transporters, and as a consequence act7 and twd1 share developmental and physiological phenotypes indicative of defects in auxin transport. These can be phenocopied by NPA treatment or by chemical actin (de) stabilization. We provide evidence that TWD1 determines downstreamlocations of auxin efflux transporters by adjusting actin filament debundling and dynamizing processes and mediating NPA action on the latter. This function appears to be evolutionary conserved since TWD1 expression in budding yeast alters actin polarization and cell polarity and provides NPA sensitivity.

Návaznosti

EE2.3.20.0043, projekt VaV

Název: Rozvoj lidských zdrojů pro výzkum, vývoj a inovace v oblasti genomiky a proteomiky rostlinných systémů

GA13-40637S, projekt VaV

Název: Genetické studie k identifikaci molekulárních mechanizmů buněčné polarity a auxinového transportu v rostlinách

Investor: Grantová agentura ČR, Genetické studie k identifikaci molekulárních mechanizmu bunecné polarity a auxinového transportu v rostlinách

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

ZHU, Jinsheng; Aurelie BAILLY; Marta ZWIEWKA; Valpuri SOVERO; Martin DI DONATO; Pei GE; Jacqueline OEHRI; Bibek ARYAL; Pengchao HAO; Miriam LINNERT; Noelia Ines BURGARDT; Christian LUCKE; Matthias WEIWAD; Max MICHEL; Oliver H. WEIERGRABER; Stephan POLLMANN; Elisa AZZARELLO; Stefano MANCUSO; Noel FERRO; Yoichiro FUKAO; Celine HOFFMANN; Roland WEDLICH-SOLDNER; Jiri FRIML; Clement THOMAS a Markus GEISLER. TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics. Plant Cell. ROCKVILLE: AMER SOC PLANT BIOLOGISTS, 2016, roč. 28, č. 4, s. 930-948. ISSN 1040-4651. Dostupné z: https://doi.org/10.1105/tpc.15.00726.

@article{1373986,
   author = {Zhu, Jinsheng and Bailly, Aurelie and Zwiewka, Marta and Sovero, Valpuri and Di Donato, Martin and Ge, Pei and Oehri, Jacqueline and Aryal, Bibek and Hao, Pengchao and Linnert, Miriam and Burgardt, Noelia Ines and Lucke, Christian and Weiwad, Matthias and Michel, Max and Weiergraber, Oliver H. and Pollmann, Stephan and Azzarello, Elisa and Mancuso, Stefano and Ferro, Noel and Fukao, Yoichiro and Hoffmann, Celine and WedlichandSoldner, Roland and Friml, Jiri and Thomas, Clement and Geisler, Markus},
   article_location = {ROCKVILLE},
   article_number = {4},
   doi = {https://doi.org/10.1105/tpc.15.00726},
   keywords = {ACID-BINDING PROTEIN; ARABIDOPSIS-THALIANA; PLASMA-MEMBRANE; PLANT DEVELOPMENT; ABC TRANSPORTERS; P-GLYCOPROTEINS; CORTICAL ARRAY; INTRACELLULAR TRAFFICKING; FUNCTIONALLY INTERACTS; EFFLUX TRANSPORTER},
   language = {eng},
   issn = {1040-4651},
   journal = {Plant Cell},
   title = {TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics},
   url = {http://www.plantcell.org/content/28/4/930},
   volume = {28},
   year = {2016}
}

TY  - JOUR
ID  - 1373986
AU  - Zhu, Jinsheng - Bailly, Aurelie - Zwiewka, Marta - Sovero, Valpuri - Di Donato, Martin - Ge, Pei - Oehri, Jacqueline - Aryal, Bibek - Hao, Pengchao - Linnert, Miriam - Burgardt, Noelia Ines - Lucke, Christian - Weiwad, Matthias - Michel, Max - Weiergraber, Oliver H. - Pollmann, Stephan - Azzarello, Elisa - Mancuso, Stefano - Ferro, Noel - Fukao, Yoichiro - Hoffmann, Celine - Wedlich-Soldner, Roland - Friml, Jiri - Thomas, Clement - Geisler, Markus
PY  - 2016
TI  - TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics
JF  - Plant Cell
VL  - 28
IS  - 4
SP  - 930-948
EP  - 930-948
PB  - AMER SOC PLANT BIOLOGISTS
SN  - 10404651
KW  - ACID-BINDING PROTEIN
KW  - ARABIDOPSIS-THALIANA
KW  - PLASMA-MEMBRANE
KW  - PLANT DEVELOPMENT
KW  - ABC TRANSPORTERS
KW  - P-GLYCOPROTEINS
KW  - CORTICAL ARRAY
KW  - INTRACELLULAR TRAFFICKING
KW  - FUNCTIONALLY INTERACTS
KW  - EFFLUX TRANSPORTER
UR  - http://www.plantcell.org/content/28/4/930
L2  - http://www.plantcell.org/content/28/4/930
N2  - Plant growth and architecture is regulated by the polar distribution of the hormone auxin. Polarity and flexibility of this process is provided by constant cycling of auxin transporter vesicles along actin filaments, coordinated by a positive auxin-actin feedback loop. Both polar auxin transport and vesicle cycling are inhibited by synthetic auxin transport inhibitors, such as 1-N-naphthylphthalamic acid (NPA), counteracting the effect of auxin; however, underlying targets and mechanisms are unclear. Using NMR, we map the NPA binding surface on the Arabidopsis thaliana ABCB chaperone TWISTED DWARF1 (TWD1). We identify ACTIN7 as a relevant, although likely indirect, TWD1 interactor, and show TWD1-dependent regulation of actin filament organization and dynamics and that TWD1 is required for NPA-mediated actin cytoskeleton remodeling. The TWD1-ACTIN7 axis controls plasma membrane presence of efflux transporters, and as a consequence act7 and twd1 share developmental and physiological phenotypes indicative of defects in auxin transport. These can be phenocopied by NPA treatment or by chemical actin (de) stabilization. We provide evidence that TWD1 determines downstreamlocations of auxin efflux transporters by adjusting actin filament debundling and dynamizing processes and mediating NPA action on the latter. This function appears to be evolutionary conserved since TWD1 expression in budding yeast alters actin polarization and cell polarity and provides NPA sensitivity.
ER  -

ZHU, Jinsheng; Aurelie BAILLY; Marta ZWIEWKA; Valpuri SOVERO; Martin DI DONATO; Pei GE; Jacqueline OEHRI; Bibek ARYAL; Pengchao HAO; Miriam LINNERT; Noelia Ines BURGARDT; Christian LUCKE; Matthias WEIWAD; Max MICHEL; Oliver H. WEIERGRABER; Stephan POLLMANN; Elisa AZZARELLO; Stefano MANCUSO; Noel FERRO; Yoichiro FUKAO; Celine HOFFMANN; Roland WEDLICH-SOLDNER; Jiri FRIML; Clement THOMAS a Markus GEISLER. TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics. \textit{Plant Cell}. ROCKVILLE: AMER SOC PLANT BIOLOGISTS, 2016, roč.~28, č.~4, s.~930-948. ISSN~1040-4651. Dostupné z: https://doi.org/10.1105/tpc.15.00726.

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