Frizzleds and WNT/beta-catenin signaling - The black box of
ligand-receptor selectivity, complex stoichiometry and
activation kinetics

J 2015

Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

SCHULTE, Gunnar

Základní údaje

Originální název

Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

Autoři

SCHULTE, Gunnar (276 Německo, garant, domácí)

Vydání

European Journal of Pharmacology, AMSTERDAM, Elsevier, 2015, 0014-2999

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.730

Kód RIV

RIV/00216224:14310/15:00088753

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.ejphar.2015.05.031

UT WoS

000361822600009

EID Scopus

2-s2.0-84942370943

Klíčová slova anglicky

Receptor complex; Canonical signaling; GPCR; LRP5/6; Class Frizzled

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 4. 2017 10:57, Ing. Andrea Mikešková

Anotace

V originále

The lipoglycoproteins of the mammalian WNT family induce beta-catenin-dependent signaling through interaction with members of the Class Frizzled receptors and LDL receptor-related protein 5/6 (LRP5/6) albeit with unknown selectivity. The 10 mammalian Frizzleds (FZDs) are seven transmembrane (7TM) spanning receptors and have recently been classified as G protein-coupled receptors (GPCRs). This review summarizes the current knowledge about WNT/FZD selectivity and functional selectivity, the role of co-receptors for signal specification, the formation of receptor complexes as well as the kinetics and mechanisms of signal initiation with focus on WNT/beta-catenin signaling. In order to exploit the true therapeutic potential of WNT/FZD signaling to treat human disease, it is clear that substantial progress in the understanding of receptor complex formation and signal specification has to precede a mechanism-based drug design targeting WNT receptors. (C) 2015 Elsevier B.V. All rights reserved

Návaznosti

EE2.3.20.0180, projekt VaV

Název: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny

GA13-32990S, projekt VaV

Název: Posttranslační modifikace receptorů na buněčném povrchu jako určující faktor pro specificitu signálu

Investor: Grantová agentura ČR, Posttranslační modifikace receptorů na buněčném povrchu jako určující faktor pro specificitu signálu

Citovat

SCHULTE, Gunnar. Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics. European Journal of Pharmacology. AMSTERDAM: Elsevier, 2015, roč. 763, September, s. 191-195. ISSN 0014-2999. Dostupné z: https://dx.doi.org/10.1016/j.ejphar.2015.05.031.

@article{1375032,
   author = {Schulte, Gunnar},
   article_location = {AMSTERDAM},
   article_number = {September},
   doi = {http://dx.doi.org/10.1016/j.ejphar.2015.05.031},
   keywords = {Receptor complex; Canonical signaling; GPCR; LRP5/6; Class Frizzled},
   language = {eng},
   issn = {0014-2999},
   journal = {European Journal of Pharmacology},
   title = {Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics},
   url = {http://www.sciencedirect.com/science/article/pii/S0014299915300157},
   volume = {763},
   year = {2015}
}

TY  - JOUR
ID  - 1375032
AU  - Schulte, Gunnar
PY  - 2015
TI  - Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics
JF  - European Journal of Pharmacology
VL  - 763
IS  - September
SP  - 191-195
EP  - 191-195
PB  - Elsevier
SN  - 00142999
KW  - Receptor complex
KW  - Canonical signaling
KW  - GPCR
KW  - LRP5/6
KW  - Class Frizzled
UR  - http://www.sciencedirect.com/science/article/pii/S0014299915300157
L2  - http://www.sciencedirect.com/science/article/pii/S0014299915300157
N2  - The lipoglycoproteins of the mammalian WNT family induce beta-catenin-dependent signaling through interaction with members of the Class Frizzled receptors and LDL receptor-related protein 5/6 (LRP5/6) albeit with unknown selectivity. The 10 mammalian Frizzleds (FZDs) are seven transmembrane (7TM) spanning receptors and have recently been classified as G protein-coupled receptors (GPCRs). This review summarizes the current knowledge about WNT/FZD selectivity and functional selectivity, the role of co-receptors for signal specification, the formation of receptor complexes as well as the kinetics and mechanisms of signal initiation with focus on WNT/beta-catenin signaling. In order to exploit the true therapeutic potential of WNT/FZD signaling to treat human disease, it is clear that substantial progress in the understanding of receptor complex formation and signal specification has to precede a mechanism-based drug design targeting WNT receptors. (C) 2015 Elsevier B.V. All rights reserved
ER  -

SCHULTE, Gunnar. Frizzleds and WNT/beta-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics. \textit{European Journal of Pharmacology}. AMSTERDAM: Elsevier, 2015, roč.~763, September, s.~191-195. ISSN~0014-2999. Dostupné z: https://dx.doi.org/10.1016/j.ejphar.2015.05.031.

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