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@article{1375134, author = {Raxwal, Vivek Kumar and Říha, Karel}, article_location = {AMSTERDAM}, article_number = {12}, doi = {http://dx.doi.org/10.1016/j.bbagrm.2016.09.001}, keywords = {Cryptic genetic variation; Evolvability; Gene duplication; NB-LRR immune receptors; Plant defense}, language = {eng}, issn = {1874-9399}, journal = {BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS}, title = {Nonsense mediated RNA decay and evolutionary capacitance}, url = {http://www.sciencedirect.com/science/article/pii/S1874939916301869}, volume = {1859}, year = {2016} }
TY - JOUR ID - 1375134 AU - Raxwal, Vivek Kumar - Říha, Karel PY - 2016 TI - Nonsense mediated RNA decay and evolutionary capacitance JF - BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS VL - 1859 IS - 12 SP - 1538-1543 EP - 1538-1543 PB - ELSEVIER SCIENCE BV SN - 18749399 KW - Cryptic genetic variation KW - Evolvability KW - Gene duplication KW - NB-LRR immune receptors KW - Plant defense UR - http://www.sciencedirect.com/science/article/pii/S1874939916301869 L2 - http://www.sciencedirect.com/science/article/pii/S1874939916301869 N2 - Nonsense mediated RNA decay (NMD) is well-known as an RNA quality control mechanism that sequesters a substantial portion of RNA from expression by targeting it for degradation. However, a number of recent studies across a range of organisms indicate a broader role for NMD in gene regulation and transcriptome homeostasis. Here we propose a novel role for NMD as a buffering system with the capability of accumulating and subsequently releasing a wide spectrum of cryptic genetic variation in response to environmental stimuli, and hence facilitating adaptive evolution. We discuss this role for NMD in the context of evolution of plant pathogen defense, whereby NMD may promote rapid diversification of intracellular immune receptors by mitigating the potentially harmful impact of their newly formed variants on plant fitness. (C) 2016 Elsevier B.V. All rights reserved. ER -
RAXWAL, Vivek Kumar a Karel ŘÍHA. Nonsense mediated RNA decay and evolutionary capacitance. \textit{BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS}. AMSTERDAM: ELSEVIER SCIENCE BV, 2016, roč.~1859, č.~12, s.~1538-1543. ISSN~1874-9399. Dostupné z: https://dx.doi.org/10.1016/j.bbagrm.2016.09.001.
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