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@article{1375134,
author = {Raxwal, Vivek Kumar and Říha, Karel},
article_location = {AMSTERDAM},
article_number = {12},
doi = {http://dx.doi.org/10.1016/j.bbagrm.2016.09.001},
keywords = {Cryptic genetic variation; Evolvability; Gene duplication; NB-LRR immune receptors; Plant defense},
language = {eng},
issn = {1874-9399},
journal = {BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS},
title = {Nonsense mediated RNA decay and evolutionary capacitance},
url = {http://www.sciencedirect.com/science/article/pii/S1874939916301869},
volume = {1859},
year = {2016}
}
TY - JOUR
ID - 1375134
AU - Raxwal, Vivek Kumar - Říha, Karel
PY - 2016
TI - Nonsense mediated RNA decay and evolutionary capacitance
JF - BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
VL - 1859
IS - 12
SP - 1538-1543
EP - 1538-1543
PB - ELSEVIER SCIENCE BV
SN - 18749399
KW - Cryptic genetic variation
KW - Evolvability
KW - Gene duplication
KW - NB-LRR immune receptors
KW - Plant defense
UR - http://www.sciencedirect.com/science/article/pii/S1874939916301869
L2 - http://www.sciencedirect.com/science/article/pii/S1874939916301869
N2 - Nonsense mediated RNA decay (NMD) is well-known as an RNA quality control mechanism that sequesters a substantial portion of RNA from expression by targeting it for degradation. However, a number of recent studies across a range of organisms indicate a broader role for NMD in gene regulation and transcriptome homeostasis. Here we propose a novel role for NMD as a buffering system with the capability of accumulating and subsequently releasing a wide spectrum of cryptic genetic variation in response to environmental stimuli, and hence facilitating adaptive evolution. We discuss this role for NMD in the context of evolution of plant pathogen defense, whereby NMD may promote rapid diversification of intracellular immune receptors by mitigating the potentially harmful impact of their newly formed variants on plant fitness. (C) 2016 Elsevier B.V. All rights reserved.
ER -
RAXWAL, Vivek Kumar a Karel ŘÍHA. Nonsense mediated RNA decay and evolutionary capacitance. \textit{BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS}. AMSTERDAM: ELSEVIER SCIENCE BV, 2016, roč.~1859, č.~12, s.~1538-1543. ISSN~1874-9399. Dostupné z: https://dx.doi.org/10.1016/j.bbagrm.2016.09.001.
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