TDM1 Regulation Determines the Number of Meiotic Divisions

J 2016

TDM1 Regulation Determines the Number of Meiotic Divisions

CIFUENTES, Marta; Sylvie JOLIVET; Laurence CROMER; Hirofumi HARASHIMA; Petra BULANKOVA et al.

Základní údaje

Originální název

TDM1 Regulation Determines the Number of Meiotic Divisions

Autoři

Vydání

PLOS GENETICS, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2016, 1553-7404

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/16:00088769

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; MEIOSIS-II TRANSITION; FISSION YEAST; ARABIDOPSIS; CYCLIN; PROTEINS; APC/C; PROGRESSION; EXPRESSION; INTERKINESIS

Štítky

rivok

Změněno: 13. 3. 2017 14:38, Mgr. Eva Špillingová

Anotace

V originále

Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA; 1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA; 1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.

Návaznosti

GA14-22346S, projekt VaV

Název: Funkce TDM1 proteinu v meiόze

Investor: Grantová agentura ČR, Funkce TDM1 proteinu v meiόze

Citovat

CIFUENTES, Marta; Sylvie JOLIVET; Laurence CROMER; Hirofumi HARASHIMA; Petra BULANKOVA; Charlotte RENNE; Wayne CRISMANI; Yuko NOMURA; Hirofumi NAKAGAMI; Keiko SUGIMOTO; Arp SCHNITTGER; Karel ŘÍHA a Raphael MERCIER. TDM1 Regulation Determines the Number of Meiotic Divisions. PLOS GENETICS. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2016, roč. 12, č. 2, s. nestránkováno, 22 s. ISSN 1553-7404. Dostupné z: https://doi.org/10.1371/journal.pgen.1005856.

@article{1375508,
   author = {Cifuentes, Marta and Jolivet, Sylvie and Cromer, Laurence and Harashima, Hirofumi and Bulankova, Petra and Renne, Charlotte and Crismani, Wayne and Nomura, Yuko and Nakagami, Hirofumi and Sugimoto, Keiko and Schnittger, Arp and Říha, Karel and Mercier, Raphael},
   article_location = {SAN FRANCISCO},
   article_number = {2},
   doi = {https://doi.org/10.1371/journal.pgen.1005856},
   keywords = {ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; MEIOSIS-II TRANSITION; FISSION YEAST; ARABIDOPSIS; CYCLIN; PROTEINS; APC/C; PROGRESSION; EXPRESSION; INTERKINESIS},
   language = {eng},
   issn = {1553-7404},
   journal = {PLOS GENETICS},
   title = {TDM1 Regulation Determines the Number of Meiotic Divisions},
   url = {http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856},
   volume = {12},
   year = {2016}
}

TY  - JOUR
ID  - 1375508
AU  - Cifuentes, Marta - Jolivet, Sylvie - Cromer, Laurence - Harashima, Hirofumi - Bulankova, Petra - Renne, Charlotte - Crismani, Wayne - Nomura, Yuko - Nakagami, Hirofumi - Sugimoto, Keiko - Schnittger, Arp - Říha, Karel - Mercier, Raphael
PY  - 2016
TI  - TDM1 Regulation Determines the Number of Meiotic Divisions
JF  - PLOS GENETICS
VL  - 12
IS  - 2
SP  - nestránkováno
EP  - nestránkováno
PB  - PUBLIC LIBRARY SCIENCE
SN  - 15537404
KW  - ANAPHASE-PROMOTING COMPLEX/CYCLOSOME
KW  - MEIOSIS-II TRANSITION
KW  - FISSION YEAST
KW  - ARABIDOPSIS
KW  - CYCLIN
KW  - PROTEINS
KW  - APC/C
KW  - PROGRESSION
KW  - EXPRESSION
KW  - INTERKINESIS
UR  - http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856
L2  - http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856
N2  - Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA; 1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA; 1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.
ER  -

CIFUENTES, Marta; Sylvie JOLIVET; Laurence CROMER; Hirofumi HARASHIMA; Petra BULANKOVA; Charlotte RENNE; Wayne CRISMANI; Yuko NOMURA; Hirofumi NAKAGAMI; Keiko SUGIMOTO; Arp SCHNITTGER; Karel ŘÍHA a Raphael MERCIER. TDM1 Regulation Determines the Number of Meiotic Divisions. \textit{PLOS GENETICS}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2016, roč.~12, č.~2, s.~nestránkováno, 22 s. ISSN~1553-7404. Dostupné z: https://doi.org/10.1371/journal.pgen.1005856.

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