| DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO, Eleonora FABIANOVA, Lenka FORETOVÁ, Vladimir JANOUT, Jolanta LISSOWSKA, Dana MATES, Ioan N MATES, Peter RUDNAI, David ZARIDZE a Paolo BOFFETTA. No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe. European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, 2018, roč. 27, č. 1, s. 1-5. ISSN 0959-8278. Dostupné z: https://dx.doi.org/10.1097/CEJ.0000000000000244. |
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@article{1375586,
author = {Davis, Ann and Tao, MengandHua and Chen, Jia and Scelo, Ghislaine and Bencko, Vladimir and Fabianova, Eleonora and Foretová, Lenka and Janout, Vladimir and Lissowska, Jolanta and Mates, Dana and Mates, Ioan N and Rudnai, Peter and Zaridze, David and Boffetta, Paolo},
article_location = {Philadelphia},
article_number = {1},
doi = {http://dx.doi.org/10.1097/CEJ.0000000000000244},
keywords = {epidemiology; global methylation; lung cancer; never-smoking women},
language = {eng},
issn = {0959-8278},
journal = {European Journal of Cancer Prevention},
title = {No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe},
volume = {27},
year = {2018}
}
TY - JOUR
ID - 1375586
AU - Davis, Ann - Tao, Meng-Hua - Chen, Jia - Scelo, Ghislaine - Bencko, Vladimir - Fabianova, Eleonora - Foretová, Lenka - Janout, Vladimir - Lissowska, Jolanta - Mates, Dana - Mates, Ioan N - Rudnai, Peter - Zaridze, David - Boffetta, Paolo
PY - 2018
TI - No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe
JF - European Journal of Cancer Prevention
VL - 27
IS - 1
SP - 1-5
EP - 1-5
PB - Lippincott Williams & Wilkins
SN - 09598278
KW - epidemiology
KW - global methylation
KW - lung cancer
KW - never-smoking women
N2 - Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case–control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.
ER -
DAVIS, Ann, Meng-Hua TAO, Jia CHEN, Ghislaine SCELO, Vladimir BENCKO, Eleonora FABIANOVA, Lenka FORETOVÁ, Vladimir JANOUT, Jolanta LISSOWSKA, Dana MATES, Ioan N MATES, Peter RUDNAI, David ZARIDZE a Paolo BOFFETTA. No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe. \textit{European Journal of Cancer Prevention}. Philadelphia: Lippincott Williams \&{} Wilkins, 2018, roč.~27, č.~1, s.~1-5. ISSN~0959-8278. Dostupné z: https://dx.doi.org/10.1097/CEJ.0000000000000244.
|
