Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is
associated with Alzheimer's disease and body mass index

J 2016

Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

ŠERÝ, Omar; Lýdia HLINECKÁ; Jana POVOVA; Ondřej BONCZEK; Tomáš ZEMAN et al.

Základní údaje

Originální název

Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

Autoři

ŠERÝ, Omar; Lýdia HLINECKÁ; Jana POVOVA; Ondřej BONCZEK; Tomáš ZEMAN; Vladimír JANOUT; Petr AMBROZ; Naim Akhtar KHAN a Vladimír Josef BALCAR

Vydání

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2016, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.295

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/16:00088953

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism

Štítky

AKR, rivok

Změněno: 30. 3. 2017 10:21, Ing. Andrea Mikešková

Anotace

V originále

Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.

Návaznosti

NT11152, projekt VaV

Název: Epidemiologie a genetika Alzheimerovy choroby

Citovat

ŠERÝ, Omar; Lýdia HLINECKÁ; Jana POVOVA; Ondřej BONCZEK; Tomáš ZEMAN; Vladimír JANOUT; Petr AMBROZ; Naim Akhtar KHAN a Vladimír Josef BALCAR. Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2016, roč. 362, March, s. 27-32. ISSN 0022-510X. Dostupné z: https://doi.org/10.1016/j.jns.2016.01.022.

@article{1376198,
   author = {Šerý, Omar and Hlinecká, Lýdia and Povova, Jana and Bonczek, Ondřej and Zeman, Tomáš and Janout, Vladimír and Ambroz, Petr and Khan, Naim Akhtar and Balcar, Vladimír Josef},
   article_location = {Netherlands},
   article_number = {March},
   doi = {https://doi.org/10.1016/j.jns.2016.01.022},
   keywords = {Alzheimer's disease; Arachidonic acid; Association; Caffeic acid; Curcumin; FLAP; Genetics; Inflammation; Leukotrienes; Polymorphism},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index},
   volume = {362},
   year = {2016}
}

TY  - JOUR
ID  - 1376198
AU  - Šerý, Omar - Hlinecká, Lýdia - Povova, Jana - Bonczek, Ondřej - Zeman, Tomáš - Janout, Vladimír - Ambroz, Petr - Khan, Naim Akhtar - Balcar, Vladimír Josef
PY  - 2016
TI  - Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
JF  - Journal of the neurological sciences
VL  - 362
IS  - March
SP  - 27-32
EP  - 27-32
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - Alzheimer's disease
KW  - Arachidonic acid
KW  - Association
KW  - Caffeic acid
KW  - Curcumin
KW  - FLAP
KW  - Genetics
KW  - Inflammation
KW  - Leukotrienes
KW  - Polymorphism
N2  - Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5-lipoxygenase (5-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p = 0.0001), while AA genotype does so 1.79-fold (p = 0.0001). In addition, GG genotype of rs4769874 polymorphism is associated with a modest increase in body mass index (BMI). We discuss potential biochemical mechanisms linking the SNP to AD and suggest possible preventive pharmacotherapies some of which are based on commonly available natural products. Finally, we set the newly identified AD risk factors into a broader context of similar CVD risk factors to generate a more comprehensive picture of interacting genetics and life-style habits potentially leading to the deteriorating mental health in the old age.
ER  -

ŠERÝ, Omar; Lýdia HLINECKÁ; Jana POVOVA; Ondřej BONCZEK; Tomáš ZEMAN; Vladimír JANOUT; Petr AMBROZ; Naim Akhtar KHAN a Vladimír Josef BALCAR. Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2016, roč.~362, March, s.~27-32. ISSN~0022-510X. Dostupné z: https://doi.org/10.1016/j.jns.2016.01.022.

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