Association of genetic polymorphism with fat and bitter taste
modalities in obese participants

a 2016

Association of genetic polymorphism with fat and bitter taste modalities in obese participants

SAYED, Amira; Inchirah KARMOUS; Jiří PLESNÍK; Omar ŠERÝ; Abdelmajid ABID et al.

Základní údaje

Originální název

Association of genetic polymorphism with fat and bitter taste modalities in obese participants

Autoři

SAYED, Amira; Inchirah KARMOUS; Jiří PLESNÍK; Omar ŠERÝ; Abdelmajid ABID; Abdallah AOUIDET a Naim Akhtar KHAN

Vydání

25th Anniversary of the FEPS, 168th Anniversary of French Physiological Society, Paris (France), June 29th – July 1st 2016, 2016

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30105 Physiology

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.867

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/16:00093960

Organizační jednotka

Přírodovědecká fakulta

ISSN

UT WoS

000379514000060

Klíčová slova anglicky

taste; obesity; CD36; gene; polymorphism

Změněno: 15. 7. 2020 14:30, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Orosensory perception of food strongly affects the ingestive behavior and intake of nutrients. The genetic variation in the genes encoding taste receptors also modulate the orosensory properties in human beings. The aim of this study was to evaluate the polymorphism in genes encoding bitter and lipid taste receptor in lean and obese subjects. We conducted our study on lean (n = 53) and obese (n = 53) participants that were recruited in National Institute of Nutrition (Tunis). We isolated the genomic DNA from the saliva swabs and, by employing restriction-fragment polymorphism (RFLP), we looked for the single nucleotide polymorphism (SNP) of two genes, CD36 (fat taste) and TAS2R38 (bitter taste). The CD36 gene variant was rs1761667 and TAS2R38 gene variants were rs1726866 and rs10246939. We noticed that A-genotype of rs1761667 was positively associated with obesity. Similarly, A-genotype and C-genotype, respectively of two rs1726866 and rs10246939 were associated with obesity. Our study shows that fat taste and bitter taste modalities play an important role in obesity.

Návaznosti

MUNI/A/1265/2015, interní kód MU

Název: Podpora biochemického výzkumu v roce 2016

Investor: Masarykova univerzita, Podpora biochemického výzkumu v roce 2016, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

SAYED, Amira; Inchirah KARMOUS; Jiří PLESNÍK; Omar ŠERÝ; Abdelmajid ABID; Abdallah AOUIDET a Naim Akhtar KHAN. Association of genetic polymorphism with fat and bitter taste modalities in obese participants. In 25th Anniversary of the FEPS, 168th Anniversary of French Physiological Society, Paris (France), June 29th – July 1st 2016. 2016. ISSN 1748-1708.

@proceedings{1376206,
   author = {Sayed, Amira and Karmous, Inchirah and Plesník, Jiří and Šerý, Omar and Abid, Abdelmajid and Aouidet, Abdallah and Khan, Naim Akhtar},
   booktitle = {25th Anniversary of the FEPS, 168th Anniversary of French Physiological Society, Paris (France), June 29th – July 1st 2016},
   keywords = {taste; obesity; CD36; gene; polymorphism},
   language = {eng},
   title = {Association of genetic polymorphism with fat and bitter taste modalities in obese participants},
   url = {http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=R1ur1bwFzJA9Zw8N7L9&page=1&doc=4},
   year = {2016}
}

TY  - CONF
ID  - 1376206
AU  - Sayed, Amira - Karmous, Inchirah - Plesník, Jiří - Šerý, Omar - Abid, Abdelmajid - Aouidet, Abdallah - Khan, Naim Akhtar
PY  - 2016
TI  - Association of genetic polymorphism with fat and bitter taste modalities in obese participants
KW  - taste
KW  - obesity
KW  - CD36
KW  - gene
KW  - polymorphism
UR  - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=R1ur1bwFzJA9Zw8N7L9&page=1&doc=4
N2  - Orosensory perception of food strongly affects the ingestive behavior and intake of nutrients. The genetic variation in the genes encoding taste receptors also modulate the orosensory properties in human beings. The aim of this study was to evaluate the polymorphism in genes encoding bitter and lipid taste receptor in lean and obese subjects. We conducted our study on lean (n = 53) and obese (n = 53) participants that were recruited in National Institute of Nutrition (Tunis). We isolated the genomic DNA from the saliva swabs and, by employing restriction-fragment polymorphism (RFLP), we looked for the single nucleotide polymorphism (SNP) of two genes, CD36 (fat taste) and TAS2R38 (bitter taste). The CD36 gene variant was rs1761667 and TAS2R38 gene variants were rs1726866 and rs10246939. We noticed that A-genotype of rs1761667 was positively associated with obesity. Similarly, A-genotype and C-genotype, respectively of two rs1726866 and rs10246939 were associated with obesity. Our study shows that fat taste and bitter taste modalities play an important role in obesity.
ER  -

SAYED, Amira; Inchirah KARMOUS; Jiří PLESNÍK; Omar ŠERÝ; Abdelmajid ABID; Abdallah AOUIDET a Naim Akhtar KHAN. Association of genetic polymorphism with fat and bitter taste modalities in obese participants. In \textit{25th Anniversary of the FEPS, 168th Anniversary of French Physiological Society, Paris (France), June 29th – July 1st 2016}. 2016. ISSN~1748-1708.

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