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@article{1376816, author = {Plevka, Pavel and Perera, Rushika and Cardosa, Jane and Kuhn, Richard J. and Rossmann, Michael G.}, article_location = {WASHINGTON}, article_number = {6086}, doi = {http://dx.doi.org/10.1126/science.1218713}, keywords = {PICORNAVIRUS; RECEPTOR; DISEASE}, language = {eng}, issn = {0036-8075}, journal = {Science}, title = {Crystal Structure of Human Enterovirus 71}, volume = {336}, year = {2012} }
TY - JOUR ID - 1376816 AU - Plevka, Pavel - Perera, Rushika - Cardosa, Jane - Kuhn, Richard J. - Rossmann, Michael G. PY - 2012 TI - Crystal Structure of Human Enterovirus 71 JF - Science VL - 336 IS - 6086 SP - 1274 EP - 1274 PB - AMER ASSOC ADVANCEMENT SCIENCE SN - 00368075 KW - PICORNAVIRUS KW - RECEPTOR KW - DISEASE N2 - Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket. ER -
PLEVKA, Pavel, Rushika PERERA, Jane CARDOSA, Richard J. KUHN a Michael G. ROSSMANN. Crystal Structure of Human Enterovirus 71. \textit{Science}. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2012, roč.~336, č.~6086, s.~1274. ISSN~0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.1218713.
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