Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane
Nanofibers Coated by Amine-rich Plasma Polymers

D 2017

Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

KEDROŇOVÁ, Eva, Vojtěch KUPKA, Anton MANAKHOV, Adrian STOICA, Lucy VOJTOVÁ et. al.

Základní údaje

Originální název

Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

Autoři

KEDROŇOVÁ, Eva (203 Česká republika, domácí), Vojtěch KUPKA (203 Česká republika), Anton MANAKHOV (643 Rusko, domácí), Adrian STOICA (642 Rumunsko, domácí), Lucy VOJTOVÁ (203 Česká republika) a Lenka ZAJÍČKOVÁ (203 Česká republika, garant, domácí)

Vydání

Ostrava, Nanocon 2016 - Proceedings, od s. 490-496, 7 s. 2017

Nakladatel

Tanger Ltd.

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10302 Condensed matter physics

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Kód RIV

RIV/00216224:14740/17:00096398

Organizační jednotka

Středoevropský technologický institut

ISBN

978-80-87294-71-0

UT WoS

000410656100086

Klíčová slova anglicky

Electrospinning; Polymer nanofibers; Biomedical application; Plasma polymers; Amine Coatings

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 3. 2018 20:22, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The electrospinning process was employed for preparation of nanofiber substrates made of polycaprolactone (PCL), polyethylene glycol (PEG) and polyurethane (PUR). The used polymer solution and electrospinning process influenced the structure and biodegradability of the resulting nanofibers. Materials processed from PCL and PEG were imaged as well-structured nanofiber meshes, however, processing of PUR resulted as an electrosprayed film rather than nanofibers structure most likely due to the insufficient molecular weight of PUR.In order to improve the biocompatibility of the nanofibers a thin amine layer by means of the cyclopropylamineplasma polymerization in radio frequency capacitively coupled discharge was deposited on prepared nanofibrous meshes. The presence of the amine groups is supposed to enhance the adhesion and proliferation of the cells. Moreover, the possibility for further functionalizing of such nanofibers was tested on a model PUR foil made of PCL and PEG. The PUR surface was activated with amine layer via similar procedure as the nanofibers and further the grafting of chitosan was employed through carbodiimide-mediated coupling. Infrared spectroscopy confirmed successful grafting of chitosan onto the PUR surface. Overcoming the drawback of PUR nanofibers processing, e.g. by synthesizing PUR with higher molecular weight, can open possible use of the material in wound healing applications exploiting antibacterial properties of chitosan.

Návaznosti

LD15150, projekt VaV

Název: Elektrostaticky zvlákněná biodegradabilní nanovlákna pokrytá plazmově připravenými aminovými vrstvami pro využití v biomedicíně

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Elektrostaticky zvlákněná biodegradabilní nanovlákna pokrytá plazmově připravenými aminovými vrstvami pro využití v biomedicíně

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

KEDROŇOVÁ, Eva, Vojtěch KUPKA, Anton MANAKHOV, Adrian STOICA, Lucy VOJTOVÁ a Lenka ZAJÍČKOVÁ. Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers. In Nanocon 2016 - Proceedings. Ostrava: Tanger Ltd., 2017, s. 490-496. ISBN 978-80-87294-71-0.

@inproceedings{1377043,
   author = {Kedroňová, Eva and Kupka, Vojtěch and Manakhov, Anton and Stoica, Adrian and Vojtová, Lucy and Zajíčková, Lenka},
   address = {Ostrava},
   booktitle = {Nanocon 2016 - Proceedings},
   keywords = {Electrospinning; Polymer nanofibers; Biomedical application; Plasma polymers; Amine Coatings},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Ostrava},
   isbn = {978-80-87294-71-0},
   pages = {490-496},
   publisher = {Tanger Ltd.},
   title = {Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers},
   year = {2017}
}

TY  - JOUR
ID  - 1377043
AU  - Kedroňová, Eva - Kupka, Vojtěch - Manakhov, Anton - Stoica, Adrian - Vojtová, Lucy - Zajíčková, Lenka
PY  - 2017
TI  - Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers
PB  - Tanger Ltd.
CY  - Ostrava
SN  - 9788087294710
KW  - Electrospinning
KW  - Polymer nanofibers
KW  - Biomedical application
KW  - Plasma polymers
KW  - Amine Coatings
N2  - The electrospinning process was employed for preparation of nanofiber substrates made of polycaprolactone (PCL), polyethylene glycol (PEG) and polyurethane (PUR). The used polymer solution and electrospinning process influenced the structure and biodegradability of the resulting nanofibers. Materials processed from PCL and PEG were imaged as well-structured nanofiber meshes, however, processing of PUR resulted as an electrosprayed film rather than nanofibers structure most likely due to the insufficient molecular weight of PUR.In order to improve the biocompatibility of the nanofibers a thin amine layer by means of the cyclopropylamineplasma polymerization in radio frequency capacitively coupled discharge was deposited on prepared nanofibrous meshes. The presence of the amine groups is supposed to enhance the adhesion and proliferation of the cells. Moreover, the possibility for further functionalizing of such nanofibers was tested on a model PUR foil made of PCL and PEG. The PUR surface was activated with amine layer via similar procedure as the nanofibers and further the grafting of chitosan was employed through carbodiimide-mediated coupling. Infrared spectroscopy confirmed successful grafting of chitosan onto the PUR surface. Overcoming the drawback of PUR nanofibers processing, e.g. by synthesizing PUR with higher molecular weight, can open possible use of the material in wound healing applications exploiting antibacterial properties of chitosan.
ER  -

KEDROŇOVÁ, Eva, Vojtěch KUPKA, Anton MANAKHOV, Adrian STOICA, Lucy VOJTOVÁ a Lenka ZAJÍČKOVÁ. Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers. In \textit{Nanocon 2016 - Proceedings}. Ostrava: Tanger Ltd., 2017, s.~490-496. ISBN~978-80-87294-71-0.

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