Oriented clonal cell dynamics enables accurate growth and
shaping of vertebrate cartilage

J 2017

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

KAUCKA, Marketa; Tomas ZIKMUND; Marketa TESAROVA; Daniel GYLLBORG; Andreas HELLANDER et al.

Základní údaje

Originální název

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Autoři

Vydání

eLife, Cambridge, eLife Sciences Publications Ltd. 2017, 2050-084X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 7.616

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00096667

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cartilaginous structures

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 16:50, Soňa Böhmová

Anotace

V originále

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Citovat

KAUCKA, Marketa; Tomas ZIKMUND; Marketa TESAROVA; Daniel GYLLBORG; Andreas HELLANDER; Josef JAROŠ; Jozef KAISER; Julian PETERSEN; Bara SZAROWSKA; Phillip T. NEWTON; Vyacheslav DYACHUK; Lei LI; Hong QIAN; Anne-Sofie JOHANSSON; Yuji MISHINA; Joshua D CURRIE; Elly M TANAKA; Alek ERICKSON; Andrew DUDLEY; Hjalmar BRISMAR; Paul SOUTHAM; Enrico COEN; Min CHEN; Lee S WEINSTEIN; Aleš HAMPL; Ernest ARENAS; Andrei S CHAGIN; Kaj FRIED a Igor ADAMEYKO. Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. eLife. Cambridge: eLife Sciences Publications Ltd., 2017, roč. 6, e25902, s. 1-37. ISSN 2050-084X. Dostupné z: https://doi.org/10.7554/eLife.25902.

@article{1380622,
   author = {Kaucka, Marketa and Zikmund, Tomas and Tesarova, Marketa and Gyllborg, Daniel and Hellander, Andreas and Jaroš, Josef and Kaiser, Jozef and Petersen, Julian and Szarowska, Bara and Newton, Phillip T. and Dyachuk, Vyacheslav and Li, Lei and Qian, Hong and Johansson, AnneandSofie and Mishina, Yuji and Currie, Joshua D and Tanaka, Elly M and Erickson, Alek and Dudley, Andrew and Brismar, Hjalmar and Southam, Paul and Coen, Enrico and Chen, Min and Weinstein, Lee S and Hampl, Aleš and Arenas, Ernest and Chagin, Andrei S and Fried, Kaj and Adameyko, Igor},
   article_location = {Cambridge},
   article_number = {e25902},
   doi = {https://doi.org/10.7554/eLife.25902},
   keywords = {Cartilaginous structures},
   language = {eng},
   issn = {2050-084X},
   journal = {eLife},
   title = {Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage},
   volume = {6},
   year = {2017}
}

TY  - JOUR
ID  - 1380622
AU  - Kaucka, Marketa - Zikmund, Tomas - Tesarova, Marketa - Gyllborg, Daniel - Hellander, Andreas - Jaroš, Josef - Kaiser, Jozef - Petersen, Julian - Szarowska, Bara - Newton, Phillip T. - Dyachuk, Vyacheslav - Li, Lei - Qian, Hong - Johansson, Anne-Sofie - Mishina, Yuji - Currie, Joshua D - Tanaka, Elly M - Erickson, Alek - Dudley, Andrew - Brismar, Hjalmar - Southam, Paul - Coen, Enrico - Chen, Min - Weinstein, Lee S - Hampl, Aleš - Arenas, Ernest - Chagin, Andrei S - Fried, Kaj - Adameyko, Igor
PY  - 2017
TI  - Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
JF  - eLife
VL  - 6
IS  - e25902
SP  - 1-37
EP  - 1-37
PB  - eLife Sciences Publications Ltd.
SN  - 2050084X
KW  - Cartilaginous structures
N2  - Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.
ER  -

KAUCKA, Marketa; Tomas ZIKMUND; Marketa TESAROVA; Daniel GYLLBORG; Andreas HELLANDER; Josef JAROŠ; Jozef KAISER; Julian PETERSEN; Bara SZAROWSKA; Phillip T. NEWTON; Vyacheslav DYACHUK; Lei LI; Hong QIAN; Anne-Sofie JOHANSSON; Yuji MISHINA; Joshua D CURRIE; Elly M TANAKA; Alek ERICKSON; Andrew DUDLEY; Hjalmar BRISMAR; Paul SOUTHAM; Enrico COEN; Min CHEN; Lee S WEINSTEIN; Aleš HAMPL; Ernest ARENAS; Andrei S CHAGIN; Kaj FRIED a Igor ADAMEYKO. Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. \textit{eLife}. Cambridge: eLife Sciences Publications Ltd., 2017, roč.~6, e25902, s.~1-37. ISSN~2050-084X. Dostupné z: https://doi.org/10.7554/eLife.25902.

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