Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk.
MOHELNIKOVA-DUCHONOVA, Beatrice; Ondrej STROUHAL; David J. HUGHES; Ivana HOLCATOVA; Martin OLIVERIUS; Zdeněk KALA; Daniele CAMPA; Cosmeri RIZZATO; Federico CANZIAN; Raffaele PEZZILLI; Renata TALAR-WOJNAROWSKA; Ewa MALECKA-PANAS; Cosimo SPERTI; Carlo Federico ZAMBON; Serdio PEDRAZZOLI; Paola FOGAR; Anna Caterina MILANETTO; Gabriele CAPURSO; Giafranco Delle FAVE; Roberto VALENTE; Maria GAZOULI; Giuseppe MALLEO; Rita Teresa LAWLOR; Oliver STROBEL; Thilo HACKERT; Nathalia GIESE; Pavel VODICKA; Ludmila VODICKOVA; Stefano LANDI; Francesca TAVANO; Domenica GIOFFREDA; Ada PIEPOLI; Valerio PAZIENZA; Andrea MAMBRINI; Mariangela PEDATA; Maurizio CANTORE; Franco BAMBI; Stefano ERMINI; Niccola FUNEL; Radmila LEMSTROVA a Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. Scientific Reports. London: Nature Publishing Group, 2017, roč. 7, č. 43812, s. 1-11. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/srep43812.
@article{1382082, author = {MohelnikovaandDuchonova, Beatrice and Strouhal, Ondrej and Hughes, David J. and Holcatova, Ivana and Oliverius, Martin and Kala, Zdeněk and Campa, Daniele and Rizzato, Cosmeri and Canzian, Federico and Pezzilli, Raffaele and TalarandWojnarowska, Renata and MaleckaandPanas, Ewa and Sperti, Cosimo and Zambon, Carlo Federico and Pedrazzoli, Serdio and Fogar, Paola and Milanetto, Anna Caterina and Capurso, Gabriele and Fave, Giafranco Delle and Valente, Roberto and Gazouli, Maria and Malleo, Giuseppe and Lawlor, Rita Teresa and Strobel, Oliver and Hackert, Thilo and Giese, Nathalia and Vodicka, Pavel and Vodickova, Ludmila and Landi, Stefano and Tavano, Francesca and Gioffreda, Domenica and Piepoli, Ada and Pazienza, Valerio and Mambrini, Andrea and Pedata, Mariangela and Cantore, Maurizio and Bambi, Franco and Ermini, Stefano and Funel, Niccola and Lemstrova, Radmila and Soucek, Pavel}, article_location = {London}, article_number = {43812}, doi = {https://doi.org/10.1038/srep43812}, keywords = {pancreatic cancer}, language = {eng}, issn = {2045-2322}, journal = {Scientific Reports}, title = {SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival}, volume = {7}, year = {2017} }
TY - JOUR ID - 1382082 AU - Mohelnikova-Duchonova, Beatrice - Strouhal, Ondrej - Hughes, David J. - Holcatova, Ivana - Oliverius, Martin - Kala, Zdeněk - Campa, Daniele - Rizzato, Cosmeri - Canzian, Federico - Pezzilli, Raffaele - Talar-Wojnarowska, Renata - Malecka-Panas, Ewa - Sperti, Cosimo - Zambon, Carlo Federico - Pedrazzoli, Serdio - Fogar, Paola - Milanetto, Anna Caterina - Capurso, Gabriele - Fave, Giafranco Delle - Valente, Roberto - Gazouli, Maria - Malleo, Giuseppe - Lawlor, Rita Teresa - Strobel, Oliver - Hackert, Thilo - Giese, Nathalia - Vodicka, Pavel - Vodickova, Ludmila - Landi, Stefano - Tavano, Francesca - Gioffreda, Domenica - Piepoli, Ada - Pazienza, Valerio - Mambrini, Andrea - Pedata, Mariangela - Cantore, Maurizio - Bambi, Franco - Ermini, Stefano - Funel, Niccola - Lemstrova, Radmila - Soucek, Pavel PY - 2017 TI - SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival JF - Scientific Reports VL - 7 IS - 43812 SP - 1-11 EP - 1-11 PB - Nature Publishing Group SN - 20452322 KW - pancreatic cancer N2 - Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging the SLC22A3 gene sequence and regulatory elements were selected for analysis. Of these, 22 were successfully evaluated in the discovery phase while six significant or suggestive variants entered the validation phase, comprising a total study number of 1,518 cases and 3,908 controls. In the discovery phase, rs2504938, rs9364554, and rs2457571 SNPs were significantly associated with pancreatic cancer risk. ER -
MOHELNIKOVA-DUCHONOVA, Beatrice; Ondrej STROUHAL; David J. HUGHES; Ivana HOLCATOVA; Martin OLIVERIUS; Zdeněk KALA; Daniele CAMPA; Cosmeri RIZZATO; Federico CANZIAN; Raffaele PEZZILLI; Renata TALAR-WOJNAROWSKA; Ewa MALECKA-PANAS; Cosimo SPERTI; Carlo Federico ZAMBON; Serdio PEDRAZZOLI; Paola FOGAR; Anna Caterina MILANETTO; Gabriele CAPURSO; Giafranco Delle FAVE; Roberto VALENTE; Maria GAZOULI; Giuseppe MALLEO; Rita Teresa LAWLOR; Oliver STROBEL; Thilo HACKERT; Nathalia GIESE; Pavel VODICKA; Ludmila VODICKOVA; Stefano LANDI; Francesca TAVANO; Domenica GIOFFREDA; Ada PIEPOLI; Valerio PAZIENZA; Andrea MAMBRINI; Mariangela PEDATA; Maurizio CANTORE; Franco BAMBI; Stefano ERMINI; Niccola FUNEL; Radmila LEMSTROVA a Pavel SOUCEK. SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. \textit{Scientific Reports}. London: Nature Publishing Group, 2017, roč.~7, č.~43812, s.~1-11. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/srep43812.