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@inproceedings{1385022, author = {Botka, Tibor and Růžičková, Vladislava and Svobodová, Karla and Pantůček, Roman and Petráš, Petr and Čejková, Darina and Doškař, Jiří}, address = {Germany}, booktitle = {EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology}, editor = {Carolina Garcia Sabaté}, keywords = {ETB plasmid; exfoliative toxin B; phylogeny; genome analysis}, howpublished = {tištěná verze "print"}, language = {eng}, location = {Germany}, note = {Nepřenášíme do RIV, výsledek má jen 1 stranu, podle metodiky M17+ musí mít stať ve sborníku min. 2 strany.}, pages = {122-122}, publisher = {EMBL Heidelberg, Germany}, title = {Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus}, url = {https://www.embo-embl-symposia.org/symposia/2017/EES17-05/index.html}, year = {2017} }
TY - JOUR ID - 1385022 AU - Botka, Tibor - Růžičková, Vladislava - Svobodová, Karla - Pantůček, Roman - Petráš, Petr - Čejková, Darina - Doškař, Jiří PY - 2017 TI - Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus PB - EMBL Heidelberg, Germany CY - Germany N1 - Nepřenášíme do RIV, výsledek má jen 1 stranu, podle metodiky M17+ musí mít stať ve sborníku min. 2 strany. KW - ETB plasmid KW - exfoliative toxin B KW - phylogeny KW - genome analysis UR - https://www.embo-embl-symposia.org/symposia/2017/EES17-05/index.html N2 - Staphylococcal epidermolytic diseases are caused by S. aureus strains producing exfoliative toxins A and B encoded by mobile genetic elements: plasmids and prophages. We analyzed various etb gene-positive plasmids isolated from the impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Most of the plasmids were related to archetypal plasmid pETBTY4. They shared a same core sequence, but they differed from each other in the content of additional DNA regions such as antibiotic resistance-encoding transposons. The ETB plasmids of this lineage were carried by strains of clonal complex CC121. Some of these strains also harbored exfoliative toxin A-encoding prophages. A novel distinct type of ETB plasmid originated from a prophageless impetigo strain was isolated and characterized in detail. Carrying conjugative cluster genes, as well as new variants of ETB and EDIN genes, it could be regarded as a source of a new lineage of ETB plasmids. Based on our findings, we have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids. ER -
BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Darina ČEJKOVÁ a Jiří DOŠKAŘ. Characterization of two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. In Carolina Garcia Sabaté. \textit{EMBO $|$ EMBL Symposium: New Approaches and Concepts in Microbiology}. Germany: EMBL Heidelberg, Germany, 2017, s.~122.
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