Chronic lymphocytic leukemia: A prognostic model comprising
only two biomarkers (IGHV mutational status and FISH
cytogenetics) separates patients with different outcome and
simplifies the CLL-IPI

J 2017

Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI

DELGADO, Julio, Michael DOUBEK, Tycho BAUMANN, Jana KOTAŠKOVÁ, Stefano MOLICA et. al.

Základní údaje

Originální název

Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI

Autoři

DELGADO, Julio (724 Španělsko), Michael DOUBEK (203 Česká republika, domácí), Tycho BAUMANN (724 Španělsko), Jana KOTAŠKOVÁ (203 Česká republika, domácí), Stefano MOLICA (380 Itálie), Pablo MOZAS (724 Španělsko), Alfredo RIVAS-DELGADO (724 Španělsko), Fortunato MORABITO (380 Itálie), Šárka POSPÍŠILOVÁ (203 Česká republika, garant, domácí) a Emili MONTSERRAT (724 Španělsko)

Vydání

American Journal of Hematology, Hoboken, John Wiley & Sons, 2017, 0361-8609

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.303

Kód RIV

RIV/00216224:14740/17:00095652

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/ajh.24660

UT WoS

000399299300022

EID Scopus

2-s2.0-85012996204

Klíčová slova anglicky

INDEPENDENT PREDICTOR; MULTIVARIATE-ANALYSIS; GENOMIC ABERRATIONS; SURVIVAL ANALYSIS; CD38 EXPRESSION; DOUBLING TIME; 1ST TREATMENT; TRIAL; INDEX; GENE

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 16:18, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Rai and Binet staging systems are important to predict the outcome of patients with chronic lymphocytic leukemia (CLL) but do not reflect the biologic diversity of the disease nor predict response to therapy, which ultimately shape patients' outcome. We devised a biomarkers-only CLL prognostic system based on the two most important prognostic parameters in CLL (i.e., IGHV mutational status and fluorescence in situ hybridization [FISH] cytogenetics), separating three different risk groups: (1) low-risk (mutated IGHV+no adverse FISH cytogenetics [del(17p), del(11q)]); (2) intermediate-risk (either unmutated IGHV or adverse FISH cytogenetics) and (3) high-risk (unmutated IGHV+adverse FISH cytogenetics). In 524 unselected subjects with CLL, the 10-year overall survival was 82% (95% CI 76%-88%), 52% (45%-62%), and 27% (17%-42%) for the low-, intermediate-, and high-risk groups, respectively. Patients with low-risk comprised around 50% of the series and had a life expectancy comparable to the general population. The prognostic model was fully validated in two independent cohorts, including 417 patients representative of general CLL population and 337 patients with Binet stage A CLL. The model had a similar discriminatory value as the CLL-IPI. Moreover, it applied to all patients with CLL independently of age, and separated patients with different risk within Rai or Binet clinical stages. The biomarkers-only CLL prognostic system presented here simplifies the CLL-IPI and could be useful in daily practice and to stratify patients in clinical trials.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-30015A, projekt VaV

Název: Analýza klonální heterogenity chronické lymfocytární leukemie pomoci sekvenování nové generace genu pro B-buněčný receptor. Národní studie.

NV15-31834A, projekt VaV

Název: Vliv selekce genomických poškození na průběh chronické lymfocytární leukémie

Citovat

DELGADO, Julio, Michael DOUBEK, Tycho BAUMANN, Jana KOTAŠKOVÁ, Stefano MOLICA, Pablo MOZAS, Alfredo RIVAS-DELGADO, Fortunato MORABITO, Šárka POSPÍŠILOVÁ a Emili MONTSERRAT. Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI. American Journal of Hematology. Hoboken: John Wiley & Sons, 2017, roč. 92, č. 4, s. 375-380. ISSN 0361-8609. Dostupné z: https://dx.doi.org/10.1002/ajh.24660.

@article{1387519,
   author = {Delgado, Julio and Doubek, Michael and Baumann, Tycho and Kotašková, Jana and Molica, Stefano and Mozas, Pablo and RivasandDelgado, Alfredo and Morabito, Fortunato and Pospíšilová, Šárka and Montserrat, Emili},
   article_location = {Hoboken},
   article_number = {4},
   doi = {http://dx.doi.org/10.1002/ajh.24660},
   keywords = {INDEPENDENT PREDICTOR; MULTIVARIATE-ANALYSIS; GENOMIC ABERRATIONS; SURVIVAL ANALYSIS; CD38 EXPRESSION; DOUBLING TIME; 1ST TREATMENT; TRIAL; INDEX; GENE},
   language = {eng},
   issn = {0361-8609},
   journal = {American Journal of Hematology},
   title = {Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03},
   volume = {92},
   year = {2017}
}

TY  - JOUR
ID  - 1387519
AU  - Delgado, Julio - Doubek, Michael - Baumann, Tycho - Kotašková, Jana - Molica, Stefano - Mozas, Pablo - Rivas-Delgado, Alfredo - Morabito, Fortunato - Pospíšilová, Šárka - Montserrat, Emili
PY  - 2017
TI  - Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI
JF  - American Journal of Hematology
VL  - 92
IS  - 4
SP  - 375-380
EP  - 375-380
PB  - John Wiley & Sons
SN  - 03618609
KW  - INDEPENDENT PREDICTOR
KW  - MULTIVARIATE-ANALYSIS
KW  - GENOMIC ABERRATIONS
KW  - SURVIVAL ANALYSIS
KW  - CD38 EXPRESSION
KW  - DOUBLING TIME
KW  - 1ST TREATMENT
KW  - TRIAL
KW  - INDEX
KW  - GENE
UR  - http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03
L2  - http://onlinelibrary.wiley.com/doi/10.1002/ajh.24660/abstract;jsessionid=539A218FD2C364B21D3AA16CBF9E3418.f03t03
N2  - Rai and Binet staging systems are important to predict the outcome of patients with chronic lymphocytic leukemia (CLL) but do not reflect the biologic diversity of the disease nor predict response to therapy, which ultimately shape patients' outcome. We devised a biomarkers-only CLL prognostic system based on the two most important prognostic parameters in CLL (i.e., IGHV mutational status and fluorescence in situ hybridization [FISH] cytogenetics), separating three different risk groups: (1) low-risk (mutated IGHV+no adverse FISH cytogenetics [del(17p), del(11q)]); (2) intermediate-risk (either unmutated IGHV or adverse FISH cytogenetics) and (3) high-risk (unmutated IGHV+adverse FISH cytogenetics). In 524 unselected subjects with CLL, the 10-year overall survival was 82% (95% CI 76%-88%), 52% (45%-62%), and 27% (17%-42%) for the low-, intermediate-, and high-risk groups, respectively. Patients with low-risk comprised around 50% of the series and had a life expectancy comparable to the general population. The prognostic model was fully validated in two independent cohorts, including 417 patients representative of general CLL population and 337 patients with Binet stage A CLL. The model had a similar discriminatory value as the CLL-IPI. Moreover, it applied to all patients with CLL independently of age, and separated patients with different risk within Rai or Binet clinical stages. The biomarkers-only CLL prognostic system presented here simplifies the CLL-IPI and could be useful in daily practice and to stratify patients in clinical trials.
ER  -

DELGADO, Julio, Michael DOUBEK, Tycho BAUMANN, Jana KOTAŠKOVÁ, Stefano MOLICA, Pablo MOZAS, Alfredo RIVAS-DELGADO, Fortunato MORABITO, Šárka POSPÍŠILOVÁ a Emili MONTSERRAT. Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI. \textit{American Journal of Hematology}. Hoboken: John Wiley \&{} Sons, 2017, roč.~92, č.~4, s.~375-380. ISSN~0361-8609. Dostupné z: https://dx.doi.org/10.1002/ajh.24660.

Přehled o publikaci