Two highly divergent lineages of exfoliative toxin B-encoding
plasmids revealed in impetigo strains of Staphylococcus aureus

J 2017

Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus

BOTKA, Tibor; Vladislava RŮŽIČKOVÁ; Karla SVOBODOVÁ; Roman PANTŮČEK; Petr PETRÁŠ et al.

Základní údaje

Originální název

Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus

Autoři

BOTKA, Tibor; Vladislava RŮŽIČKOVÁ; Karla SVOBODOVÁ; Roman PANTŮČEK; Petr PETRÁŠ; Darina ČEJKOVÁ a Jiří DOŠKAŘ

Vydání

International Journal of Medical Microbiology, Jena, ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2017, 1438-4221

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.298

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/17:00094338

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

Staphylococcus aureus; exfoliativní toxin B; ETB plazmidy; bulózní impetigo; fylogeneze

Klíčová slova anglicky

Staphylococcus aureus; Exfoliative toxin B; ETB plasmids; Bullous impetigo; Phylogeny

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 4. 2018 16:58, Ing. Nicole Zrilić

Anotace

V originále

Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Sharing a 33-kb core sequence including virulence genes for ETB, EDIN C, and lantibiotics, they were assigned to a stand-alone lineage, named pETBTY4-based plasmids. Differing from each other in the content of variable DNA regions, they formed four sequence types. In addition to them, a novel unique plasmid pETB608 isolated from a strain of ST130 was described. Carrying conjugative cluster genes, as well as new variants of etb and edinA genes, pETB608 could be regarded as a source of a new lineage of ETB plasmids. We have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.

Návaznosti

MUNI/A/0967/2015, interní kód MU

Název: Podpora výzkumné činnosti studentů molekulární biologie a genetiky 4 (Akronym: MBG4)

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů molekulární biologie a genetiky 4, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

QJ1510216, projekt VaV

Název: Fágová terapie infekcí vyvolaných Staphylococcus aureus v chovech hospodářských zvířat (Akronym: StafyFag)

Investor: Ministerstvo zemědělství ČR, Fágová terapie infekcí vyvolaných Staphylococcus aureus v chovech hospodářských zvířat

Přiložené soubory

1-s2.0-S1438422117301157-main.pdf

Požádat o autorskou verzi souboru

Citovat

BOTKA, Tibor; Vladislava RŮŽIČKOVÁ; Karla SVOBODOVÁ; Roman PANTŮČEK; Petr PETRÁŠ; Darina ČEJKOVÁ a Jiří DOŠKAŘ. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. International Journal of Medical Microbiology. Jena: ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2017, roč. 307, č. 6, s. 291-296. ISSN 1438-4221. Dostupné z: https://doi.org/10.1016/j.ijmm.2017.05.005.

@article{1389107,
   author = {Botka, Tibor and Růžičková, Vladislava and Svobodová, Karla and Pantůček, Roman and Petráš, Petr and Čejková, Darina and Doškař, Jiří},
   article_location = {Jena},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.ijmm.2017.05.005},
   keywords = {Staphylococcus aureus; Exfoliative toxin B; ETB plasmids; Bullous impetigo; Phylogeny},
   language = {eng},
   issn = {1438-4221},
   journal = {International Journal of Medical Microbiology},
   title = {Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus},
   url = {http://www.sciencedirect.com/science/article/pii/S1438422117301157},
   volume = {307},
   year = {2017}
}

TY  - JOUR
ID  - 1389107
AU  - Botka, Tibor - Růžičková, Vladislava - Svobodová, Karla - Pantůček, Roman - Petráš, Petr - Čejková, Darina - Doškař, Jiří
PY  - 2017
TI  - Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus
JF  - International Journal of Medical Microbiology
VL  - 307
IS  - 6
SP  - 291-296
EP  - 291-296
PB  - ELSEVIER GMBH, URBAN & FISCHER VERLAG
SN  - 14384221
KW  - Staphylococcus aureus
KW  - Exfoliative toxin B
KW  - ETB plasmids
KW  - Bullous impetigo
KW  - Phylogeny
UR  - http://www.sciencedirect.com/science/article/pii/S1438422117301157
L2  - http://www.sciencedirect.com/science/article/pii/S1438422117301157
N2  - Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Sharing a 33-kb core sequence including virulence genes for ETB, EDIN C, and lantibiotics, they were assigned to a stand-alone lineage, named pETBTY4-based plasmids. Differing from each other in the content of variable DNA regions, they formed four sequence types. In addition to them, a novel unique plasmid pETB608 isolated from a strain of ST130 was described. Carrying conjugative cluster genes, as well as new variants of etb and edinA genes, pETB608 could be regarded as a source of a new lineage of ETB plasmids. We have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.
ER  -

BOTKA, Tibor; Vladislava RŮŽIČKOVÁ; Karla SVOBODOVÁ; Roman PANTŮČEK; Petr PETRÁŠ; Darina ČEJKOVÁ a Jiří DOŠKAŘ. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. \textit{International Journal of Medical Microbiology}. Jena: ELSEVIER GMBH, URBAN \&{} FISCHER VERLAG, 2017, roč.~307, č.~6, s.~291-296. ISSN~1438-4221. Dostupné z: https://doi.org/10.1016/j.ijmm.2017.05.005.

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