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@article{1389107,
author = {Botka, Tibor and Růžičková, Vladislava and Svobodová, Karla and Pantůček, Roman and Petráš, Petr and Čejková, Darina and Doškař, Jiří},
article_location = {Jena},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.ijmm.2017.05.005},
keywords = {Staphylococcus aureus; Exfoliative toxin B; ETB plasmids; Bullous impetigo; Phylogeny},
language = {eng},
issn = {1438-4221},
journal = {International Journal of Medical Microbiology},
title = {Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus},
url = {http://www.sciencedirect.com/science/article/pii/S1438422117301157},
volume = {307},
year = {2017}
}
TY - JOUR
ID - 1389107
AU - Botka, Tibor - Růžičková, Vladislava - Svobodová, Karla - Pantůček, Roman - Petráš, Petr - Čejková, Darina - Doškař, Jiří
PY - 2017
TI - Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus
JF - International Journal of Medical Microbiology
VL - 307
IS - 6
SP - 291-296
EP - 291-296
PB - ELSEVIER GMBH, URBAN & FISCHER VERLAG
SN - 14384221
KW - Staphylococcus aureus
KW - Exfoliative toxin B
KW - ETB plasmids
KW - Bullous impetigo
KW - Phylogeny
UR - http://www.sciencedirect.com/science/article/pii/S1438422117301157
L2 - http://www.sciencedirect.com/science/article/pii/S1438422117301157
N2 - Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETBTY4. Sharing a 33-kb core sequence including virulence genes for ETB, EDIN C, and lantibiotics, they were assigned to a stand-alone lineage, named pETBTY4-based plasmids. Differing from each other in the content of variable DNA regions, they formed four sequence types. In addition to them, a novel unique plasmid pETB608 isolated from a strain of ST130 was described. Carrying conjugative cluster genes, as well as new variants of etb and edinA genes, pETB608 could be regarded as a source of a new lineage of ETB plasmids. We have designed a helpful detection assay, which facilitates the precise identification of the all described types of ETB plasmids.
ER -
BOTKA, Tibor, Vladislava RŮŽIČKOVÁ, Karla SVOBODOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Darina ČEJKOVÁ a Jiří DOŠKAŘ. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. \textit{International Journal of Medical Microbiology}. Jena: ELSEVIER GMBH, URBAN \&{} FISCHER VERLAG, 2017, roč.~307, č.~6, s.~291-296. ISSN~1438-4221. Dostupné z: https://dx.doi.org/10.1016/j.ijmm.2017.05.005.
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