2012
Bioavailability and Antioxidant Activity of Black Chokeberry (Aronia melanocarpa) Polyphenols: in vitro and in vivo Evidences and Possible Mechanisms of Action: A Review
DENEV, P; CG KRATCHANOV; Milan ČÍŽ; Antonín LOJEK; MG KRATCHANOVA et al.Základní údaje
Originální název
Bioavailability and Antioxidant Activity of Black Chokeberry (Aronia melanocarpa) Polyphenols: in vitro and in vivo Evidences and Possible Mechanisms of Action: A Review
Autoři
DENEV, P; CG KRATCHANOV; Milan ČÍŽ; Antonín LOJEK a MG KRATCHANOVA
Vydání
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, HOBOKEN, WILEY-BLACKWELL, 2012, 1541-4337
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 5.053
Označené pro přenos do RIV
Ne
UT WoS
Klíčová slova anglicky
Antioxidant activity; Aronia melanocarpa; bioavailability; chokeberry
Změněno: 12. 9. 2017 12:28, doc. RNDr. Milan Číž, Ph.D.
Anotace
V originále
Black chokeberry (Aronia melanocarpa) is a distinctive berry with a high content of polyphenol compounds and possesses one of the highest in vitro antioxidant activities among fruits. The bioavailability of aronia polyphenols seems to be low, but there is ample evidence for chokeberry health benefits including antidiabetic, cardioprotective, hepatoprotective, antimutagenic, and anticarcinogenic effects. This review presents the available information for the bioavailability and antioxidant activity of chokeberry polyphenols and explains the possible mechanisms of action in vivo in the prevention and treatment of oxidative stress-related diseases. The review shows the available data for chokeberry antioxidant activity in vitro, in isolated cells and cell lines, and in vivo, in both human subjects and animals. It is evident that in vivo antioxidant action of chokeberry extends far beyond radical scavenging and includes suppression of reactive oxygen and nitrogen species formation, inhibition of prooxidant enzymes, restoration of antioxidant enzymes, and probably cellular signaling to regulate the level of antioxidant compounds and enzymes. The original contribution of this work is that it compiles the available information up to date and outlines the gaps and future directions in the assessment of chokeberry antioxidant action in vivo.