Phagocyte-induced oxidative stress in patients with
haemodialysis treatment and organ transplantation

J 1998

Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation

LOJEK, Antonín; J CERNY; P NEMEC; J NICOVSKY; V SOSKA et al.

Základní údaje

Originální název

Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation

Autoři

LOJEK, Antonín; J CERNY; P NEMEC; J NICOVSKY; V SOSKA; Milan ČÍŽ; H SLAVIKOVA a Lukáš KUBALA

Vydání

Biofactors, ENGLAND, IOS PRESS, 1998, 0951-6433

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

DOI

https://doi.org/10.1002/biof.5520080128

UT WoS

000171767300029

Změněno: 12. 9. 2017 13:24, doc. RNDr. Milan Číž, Ph.D.

Anotace

V originále

The aim of the study was to examine the phagocyte-derived production of reactive oxygen species (ROS), lipoperoxidation and the total radical-trapping antioxidant parameter (TRAP) in patients undergoing regular haemodialysis (HD) followed by kidney transplantation (n = 13). A significant increase in both spontaneous and activated ROS generation was found during the post-transplantation period in days 1-3. This effect was caused mainly by an increased number of neutrophils. On the other hand, the TRAP parameter was decreased in HD patients. After kidney transplantation, the TRAP parameter increased, reaching the level of healthy controls at the end of the first week after surgery. Increase in MDA level was determined after HD and kidney transplantation. It can be concluded from the results obtained that phagocyte mobilisation and increased oxidative stress after HD and kidney transplantation were associated with the insufficient activity of extracellular antioxidant mechanisms resulting in increased lipid peroxidation.

Citovat

LOJEK, Antonín; J CERNY; P NEMEC; J NICOVSKY; V SOSKA; Milan ČÍŽ; H SLAVIKOVA a Lukáš KUBALA. Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation. Biofactors. ENGLAND: IOS PRESS, 1998, roč. 8, 1-2, s. 165-168. ISSN 0951-6433. Dostupné z: https://doi.org/10.1002/biof.5520080128.

@article{1389187,
   author = {Lojek, Antonín and Cerny, J and Nemec, P and Nicovsky, J and Soska, V and Číž, Milan and Slavikova, H and Kubala, Lukáš},
   article_location = {ENGLAND},
   article_number = {1-2},
   doi = {https://doi.org/10.1002/biof.5520080128},
   language = {eng},
   issn = {0951-6433},
   journal = {Biofactors},
   title = {Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation},
   volume = {8},
   year = {1998}
}

TY  - JOUR
ID  - 1389187
AU  - Lojek, Antonín - Cerny, J - Nemec, P - Nicovsky, J - Soska, V - Číž, Milan - Slavikova, H - Kubala, Lukáš
PY  - 1998
TI  - Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation
JF  - Biofactors
VL  - 8
IS  - 1-2
SP  - 165-168
EP  - 165-168
PB  - IOS PRESS
SN  - 09516433
N2  - The aim of the study was to examine the phagocyte-derived production of reactive oxygen species (ROS), lipoperoxidation and the total radical-trapping antioxidant parameter (TRAP) in patients undergoing regular haemodialysis (HD) followed by kidney transplantation (n = 13). A significant increase in both spontaneous and activated ROS generation was found during the post-transplantation period in days 1-3. This effect was caused mainly by an increased number of neutrophils. On the other hand, the TRAP parameter was decreased in HD patients. After kidney transplantation, the TRAP parameter increased, reaching the level of healthy controls at the end of the first week after surgery. Increase in MDA level was determined after HD and kidney transplantation. It can be concluded from the results obtained that phagocyte mobilisation and increased oxidative stress after HD and kidney transplantation were associated with the insufficient activity of extracellular antioxidant mechanisms resulting in increased lipid peroxidation.
ER  -

LOJEK, Antonín; J CERNY; P NEMEC; J NICOVSKY; V SOSKA; Milan ČÍŽ; H SLAVIKOVA a Lukáš KUBALA. Phagocyte-induced oxidative stress in patients with haemodialysis treatment and organ transplantation. \textit{Biofactors}. ENGLAND: IOS PRESS, 1998, roč.~8, 1-2, s.~165-168. ISSN~0951-6433. Dostupné z: https://doi.org/10.1002/biof.5520080128.

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