Staphylococcus sciuri bacteriophages double-convert for
staphylokinase and phospholipase, mediate interspecies plasmid
transduction, and package mecA gene

J 2017

Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene

ZEMAN, Michal; Ivana MAŠLAŇOVÁ; Adéla INDRÁKOVÁ; Marta ŠIBOROVÁ; Kamil MIKULÁŠEK et al.

Základní údaje

Originální název

Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene

Autoři

Vydání

Scientific Reports, London, Nature Publishing Group, 2017, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10603 Genetics and heredity

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.122

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/17:00094937

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

COAGULASE-NEGATIVE STAPHYLOCOCCI; GENOME SEQUENCE; EPIDERMIDIS BACTERIOPHAGES; AUREUS BACTERIOPHAGES; RESISTANT STRAINS; VIRULENCE GENES; PROTEIN; PHAGES; HOST; PROPHAGES

Štítky

CF CRYO, CF PROT, NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 4. 2018 23:38, Ing. Nicole Zrilić

Anotace

V originále

Staphylococcus sciuri is a bacterial pathogen associated with infections in animals and humans, and represents a reservoir for the mecA gene encoding methicillin-resistance in staphylococci. No S. sciuri siphophages were known. Here the identification and characterization of two temperate S. sciuri phages from the Siphoviridae family designated phi575 and phi879 are presented. The phages have icosahedral heads and flexible noncontractile tails that end with a tail spike. The genomes of the phages are 42,160 and 41,448?bp long and encode 58 and 55 ORFs, respectively, arranged in functional modules. Their head-tail morphogenesis modules are similar to those of Staphylococcus aureus phi13-like serogroup F phages, suggesting their common evolutionary origin. The genome of phage phi575 harbours genes for staphylokinase and phospholipase that might enhance the virulence of the bacterial hosts. In addition both of the phages package a homologue of the mecA gene, which is a requirement for its lateral transfer. Phage phi879 transduces tetracycline and aminoglycoside pSTS7-like resistance plasmids from its host to other S. sciuri strains and to S. aureus. Furthermore, both of the phages efficiently adsorb to numerous staphylococcal species, indicating that they may contribute to interspecies horizontal gene transfer.

Návaznosti

GP13-05069P, projekt VaV

Název: Horizontální přenos stafylokokové chromozomové kazety mec (SCCmec) prostřednictvím bakteriofágů napříč kmeny rodu Staphylococcus

Investor: Grantová agentura ČR, Horizontální přenos stafylokokové chromozomové kazety mec (SCCmec) prostřednictvím bakteriofágů napříč kmeny rodu Staphylococcus

LM2015043, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

Přiložené soubory

srep46319.pdf

Požádat o autorskou verzi souboru

Citovat

ZEMAN, Michal; Ivana MAŠLAŇOVÁ; Adéla INDRÁKOVÁ; Marta ŠIBOROVÁ; Kamil MIKULÁŠEK; Kamila BENDÍČKOVÁ; Pavel PLEVKA; Veronika VRBOVSKÁ; Zbyněk ZDRÁHAL; Jiří DOŠKAŘ a Roman PANTŮČEK. Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene. Scientific Reports. London: Nature Publishing Group, 2017, roč. 7, April, s. nestránkováno, 11 s. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/srep46319.

@article{1389365,
   author = {Zeman, Michal and Mašlaňová, Ivana and Indráková, Adéla and Šiborová, Marta and Mikulášek, Kamil and Bendíčková, Kamila and Plevka, Pavel and Vrbovská, Veronika and Zdráhal, Zbyněk and Doškař, Jiří and Pantůček, Roman},
   article_location = {London},
   article_number = {April},
   doi = {https://doi.org/10.1038/srep46319},
   keywords = {COAGULASE-NEGATIVE STAPHYLOCOCCI; GENOME SEQUENCE; EPIDERMIDIS BACTERIOPHAGES; AUREUS BACTERIOPHAGES; RESISTANT STRAINS; VIRULENCE GENES; PROTEIN; PHAGES; HOST; PROPHAGES},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene},
   url = {https://www.nature.com/articles/srep46319},
   volume = {7},
   year = {2017}
}

TY  - JOUR
ID  - 1389365
AU  - Zeman, Michal - Mašlaňová, Ivana - Indráková, Adéla - Šiborová, Marta - Mikulášek, Kamil - Bendíčková, Kamila - Plevka, Pavel - Vrbovská, Veronika - Zdráhal, Zbyněk - Doškař, Jiří - Pantůček, Roman
PY  - 2017
TI  - Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene
JF  - Scientific Reports
VL  - 7
IS  - April
SP  - nestránkováno
EP  - nestránkováno
PB  - Nature Publishing Group
SN  - 20452322
KW  - COAGULASE-NEGATIVE STAPHYLOCOCCI
KW  - GENOME SEQUENCE
KW  - EPIDERMIDIS BACTERIOPHAGES
KW  - AUREUS BACTERIOPHAGES
KW  - RESISTANT STRAINS
KW  - VIRULENCE GENES
KW  - PROTEIN
KW  - PHAGES
KW  - HOST
KW  - PROPHAGES
UR  - https://www.nature.com/articles/srep46319
L2  - https://www.nature.com/articles/srep46319
N2  - Staphylococcus sciuri is a bacterial pathogen associated with infections in animals and humans, and represents a reservoir for the mecA gene encoding methicillin-resistance in staphylococci. No S. sciuri siphophages were known. Here the identification and characterization of two temperate S. sciuri phages from the Siphoviridae family designated phi575 and phi879 are presented. The phages have icosahedral heads and flexible noncontractile tails that end with a tail spike. The genomes of the phages are 42,160 and 41,448?bp long and encode 58 and 55 ORFs, respectively, arranged in functional modules. Their head-tail morphogenesis modules are similar to those of Staphylococcus aureus phi13-like serogroup F phages, suggesting their common evolutionary origin. The genome of phage phi575 harbours genes for staphylokinase and phospholipase that might enhance the virulence of the bacterial hosts. In addition both of the phages package a homologue of the mecA gene, which is a requirement for its lateral transfer. Phage phi879 transduces tetracycline and aminoglycoside pSTS7-like resistance plasmids from its host to other S. sciuri strains and to S. aureus. Furthermore, both of the phages efficiently adsorb to numerous staphylococcal species, indicating that they may contribute to interspecies horizontal gene transfer.
ER  -

ZEMAN, Michal; Ivana MAŠLAŇOVÁ; Adéla INDRÁKOVÁ; Marta ŠIBOROVÁ; Kamil MIKULÁŠEK; Kamila BENDÍČKOVÁ; Pavel PLEVKA; Veronika VRBOVSKÁ; Zbyněk ZDRÁHAL; Jiří DOŠKAŘ a Roman PANTŮČEK. Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene. \textit{Scientific Reports}. London: Nature Publishing Group, 2017, roč.~7, April, s.~nestránkováno, 11 s. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/srep46319.

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