Titanocenes as Anticancer Agents: Recent Insights

J 2017

Titanocenes as Anticancer Agents: Recent Insights

SKOUPILOVÁ, Hana; Roman HRSTKA a Martin BARTOŠÍK

Základní údaje

Originální název

Titanocenes as Anticancer Agents: Recent Insights

Název česky

Titanoceny jako protinádorová léčiva: Nejnovější poznatky

Autoři

SKOUPILOVÁ, Hana; Roman HRSTKA a Martin BARTOŠÍK

Vydání

Medicinal Chemistry, 2017, 1573-4064

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.631

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.2174/1573406412666161228113650

UT WoS

000402479000003

EID Scopus

2-s2.0-85020793064

Klíčová slova česky

Chemoterapie, cisplatina, klinické testy, organometalické sloučeniny, titanocenové sloučeniny, titanocen dichlorid

Klíčová slova anglicky

Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.

Štítky

RIV ne

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2020 14:51, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Background: Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. Objectives: This review summarizes the progress in the development of organometallic titaniumbased compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Results: Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.

Citovat

SKOUPILOVÁ, Hana; Roman HRSTKA a Martin BARTOŠÍK. Titanocenes as Anticancer Agents: Recent Insights. Medicinal Chemistry. 2017, roč. 13, č. 4, s. 334 - 344. ISSN 1573-4064. Dostupné z: https://doi.org/10.2174/1573406412666161228113650.

@article{1390158,
   author = {Skoupilová, Hana and Hrstka, Roman and Bartošík, Martin},
   article_number = {4},
   doi = {https://doi.org/10.2174/1573406412666161228113650},
   keywords = {Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.},
   language = {eng},
   issn = {1573-4064},
   journal = {Medicinal Chemistry},
   note = {Žádný z autorů nemá afiliaci na MU.},
   title = {Titanocenes as Anticancer Agents: Recent Insights},
   url = {http://www.eurekaselect.com/148762/article},
   volume = {13},
   year = {2017}
}

TY  - JOUR
ID  - 1390158
AU  - Skoupilová, Hana - Hrstka, Roman - Bartošík, Martin
PY  - 2017
TI  - Titanocenes as Anticancer Agents: Recent Insights
JF  - Medicinal Chemistry
VL  - 13
IS  - 4
SP  - 334 - 344
EP  - 334 - 344
SN  - 15734064
N1  - Žádný z autorů nemá afiliaci na MU.
KW  - Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.
UR  - http://www.eurekaselect.com/148762/article
N2  - Background: Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. Objectives: This review summarizes the progress in the development of organometallic titaniumbased compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Results: Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.
ER  -

SKOUPILOVÁ, Hana; Roman HRSTKA a Martin BARTOŠÍK. Titanocenes as Anticancer Agents: Recent Insights. \textit{Medicinal Chemistry}. 2017, roč.~13, č.~4, s.~334 - 344. ISSN~1573-4064. Dostupné z: https://doi.org/10.2174/1573406412666161228113650.

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