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@article{1390248,
author = {Georgiev, YN and Paulsen, BS and Kiyohara, H and Číž, Milan and Ognyanov, MH and Vašíček, Ondřej and Rise, F and Denev, Petko and Yamada, H and Lojek, Antonín and Kussovski, V and Barsett, H and Krastanov, AI and Yanakieva, IZ and Kratchanova, MG},
article_location = {OXFORD},
doi = {http://dx.doi.org/10.1016/j.carbpol.2017.07.011},
keywords = {Lavender; Pectin; Immunomodulation; Neutrophils; Macrophages; Peyer's patches},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells},
url = {http://dx.doi.org/10.1016/j.carbpol.2017.07.011},
volume = {174},
year = {2017}
}
TY - JOUR
ID - 1390248
AU - Georgiev, YN - Paulsen, BS - Kiyohara, H - Číž, Milan - Ognyanov, MH - Vašíček, Ondřej - Rise, F - Denev, Petko - Yamada, H - Lojek, Antonín - Kussovski, V - Barsett, H - Krastanov, AI - Yanakieva, IZ - Kratchanova, MG
PY - 2017
TI - The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells
JF - Carbohydrate Polymers
VL - 174
SP - 948-959
EP - 948-959
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Lavender
KW - Pectin
KW - Immunomodulation
KW - Neutrophils
KW - Macrophages
KW - Peyer's patches
UR - http://dx.doi.org/10.1016/j.carbpol.2017.07.011
L2 - http://dx.doi.org/10.1016/j.carbpol.2017.07.011
N2 - Two pectic (chPS-L1, chPS-L2) and one polyphenolic (chPP-L) fractions were obtained from lavender flowers after boiling water extraction, exhaustive removing of alcohol-soluble molecules and SEC. chPS-L1 (52.4 kDa) contains mainly low-acetylated and high-methoxylated homogalacturonans (HG), and smaller rhamnogalacturonan (RG) I backbone fragments rich in 1,3,5-branched arabinan and arabinogalactan (AG) II side chains. chPS-L2 (21.8 kDa) contains predominantly similarly esterified HG, followed by RGI with AGII structures and RGII. The prevalence of catechin and epicatechin in chPP-L indicates that they form weak interactions with pectins. chPS-L1 and chPS-L2 enhanced beta(2)-integrin expression on neutrophils, inducing ROS generation and macrophage NO production. Both the effects on beta(2)-integrin and high complement fixation activity of chPS-L1 were proposed for its inhibitory action against PMA-and OZP-activated ROS formation. This, together with suppression of NO generation after co-stimulation with chPS-L1 and LPS, suggested anti-inflammatory activity of studied pectins. Lavender polysaccharides expressed intestinal Peyer's patch immunomodulating activity. (C) 2017 Elsevier Ltd. All rights reserved.
ER -
GEORGIEV, YN, BS PAULSEN, H KIYOHARA, Milan ČÍŽ, MH OGNYANOV, Ondřej VAŠÍČEK, F RISE, Petko DENEV, H YAMADA, Antonín LOJEK, V KUSSOVSKI, H BARSETT, AI KRASTANOV, IZ YANAKIEVA a MG KRATCHANOVA. The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells. \textit{Carbohydrate Polymers}. OXFORD: ELSEVIER SCI LTD, 2017, roč.~174, s.~948-959. ISSN~0144-8617. Dostupné z: https://dx.doi.org/10.1016/j.carbpol.2017.07.011.
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