MAJEROVA, Petra, Peter BARATH, Alena MICHALICOVA, Stanislav KATINA, Michal NOVAK a Andrej KOVAC. Changes of Cerebrospinal Fluid Peptides due to Tauopathy. Journal of Alzheimer’s Disease, Amsterdam: IOS Press, 2017, roč. 58, č. 2, s. 507-519. ISSN 1387-2877. doi:10.3233/JAD-170110.
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Základní údaje
Originální název Changes of Cerebrospinal Fluid Peptides due to Tauopathy
Autoři MAJEROVA, Petra (703 Slovensko), Peter BARATH (703 Slovensko), Alena MICHALICOVA (703 Slovensko), Stanislav KATINA (703 Slovensko, garant, domácí), Michal NOVAK (703 Slovensko) a Andrej KOVAC (703 Slovensko).
Vydání Journal of Alzheimer’s Disease, Amsterdam, IOS Press, 2017, 1387-2877.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Statistics and probability
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 3.476
Kód RIV RIV/00216224:14310/17:00095001
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.3233/JAD-170110
UT WoS 000402994400018
Klíčová slova anglicky Cerebrospinal fluid; LC-MALDI MS; peptidomics; rat model; tauopathy
Štítky NZ, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Nicole Zrilić, učo 240776. Změněno: 5. 4. 2018 09:47.
Anotace
Alzheimer’s disease (AD) and progressive supranuclear palsy are two common neurodegenerative tauopathies, and the most common cause of progressive brain dementia in elderly affecting more than 35 million people. The tauopathies are characterized by abnormal deposition of microtubule associated protein tau into intracellular neurofibrillary tangles composed mainly of the hyperphosphorylated form of the protein. The diagnosis of tauopathies is based on the presence of clinical features and pathological changes. Over the last decade, there has been an intensive search for novel biochemical markers for clinical diagnosis of AD and other tauopathies. In the present study, we used transgenic rat model for tauopathy expressing human truncated tau protein (aa 151–391/4R) to analyze the cerebrospinal fluid (CSF) peptidome using liquid chromatography – matrix assisted laser desorption/ionization mass spectrometry (LC-MALDI TOF/TOF). From 345 peptides, we identified a total of 175 proteins. Among them, 17 proteins were significantly altered in the CSF of transgenic rats. The following proteins were elevated in the CSF of transgenic rats when compared to the control animals: neurofilament light and medium chain, apolipoprotein E, gamma-synuclein, chromogranin A, reticulon-4, secretogranin-2, calsyntein-1 and -3, endothelin-3, neuroendocrine protein B72A, alpha-1-macroglobulin, and augurin. Interestingly most of the identified proteins were previously linked to AD and other tauopathies, indicating the significance of transgenic animals in biomarker validation.
Návaznosti
GA15-06991S, projekt VaVNázev: Analýza funkcionálních dat a související témata
Investor: Grantová agentura ČR, Standardní projekty
VytisknoutZobrazeno: 16. 9. 2019 10:52