Abiotic synthesis of amino acids and self-crystallization under
prebiotic conditions

J 2014

Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions

JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON et. al.

Základní údaje

Originální název

Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions

Autoři

JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA

Vydání

Scientific Reports, LONDON, NATURE PUBLISHING GROUP, 2014, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.578

DOI

http://dx.doi.org/10.1038/srep06769

UT WoS

000343978700001

Změněno: 29. 9. 2017 13:44, PharmDr. Zdeněk Spáčil, Ph.D.

Anotace

V originále

Building on previous research on the origin and homochirality of life, this study focuses on analyses profiling important building blocks of life: the natural amino acids. The spark discharge variation of the iconic Miller experiment was performed with a reducing gas mixture of ammonia, methane, water and hydrogen. Amino acid analysis using liquid chromatography coupled with tandem mass spectrometry after pre-column derivatizaiton revealed the generation of several amino acids including those essential for life. Re-crystallization of the synthetic products and enantiomeric ratio analysis were subsequently performed. Results from liquid chromatography coupled with either fluorescent detector or tandem mass spectrometry after pre-column derivatization with chiral reagent revealed spontaneous and effective asymmetric resolution of serine and alanine. This work describes a useful analytical platform for investigation of hypotheses regarding the origin and homochirality of amino acids under prebiotic conditions. The formation of numerous amino acids in the electric discharge experiment and the occurrence of high enantiomeric ratios of amino acids in re-crystallization experiment give valuable implications for future studies in unraveling fundamental questions regarding origins and evolution of life.

Citovat

JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA. Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2014, roč. 4, 6 s. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep06769.

@article{1391008,
   author = {Jiang, LY and Dziedzic, P and Spáčil, Zdeněk and Zhao, GL and Nilsson, L and Ilag, LL and Cordova, A},
   article_location = {LONDON},
   doi = {http://dx.doi.org/10.1038/srep06769},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1391008
AU  - Jiang, LY - Dziedzic, P - Spáčil, Zdeněk - Zhao, GL - Nilsson, L - Ilag, LL - Cordova, A
PY  - 2014
TI  - Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions
JF  - Scientific Reports
VL  - 4
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
N2  - Building on previous research on the origin and homochirality of life, this study focuses on analyses profiling important building blocks of life: the natural amino acids. The spark discharge variation of the iconic Miller experiment was performed with a reducing gas mixture of ammonia, methane, water and hydrogen. Amino acid analysis using liquid chromatography coupled with tandem mass spectrometry after pre-column derivatizaiton revealed the generation of several amino acids including those essential for life. Re-crystallization of the synthetic products and enantiomeric ratio analysis were subsequently performed. Results from liquid chromatography coupled with either fluorescent detector or tandem mass spectrometry after pre-column derivatization with chiral reagent revealed spontaneous and effective asymmetric resolution of serine and alanine. This work describes a useful analytical platform for investigation of hypotheses regarding the origin and homochirality of amino acids under prebiotic conditions. The formation of numerous amino acids in the electric discharge experiment and the occurrence of high enantiomeric ratios of amino acids in re-crystallization experiment give valuable implications for future studies in unraveling fundamental questions regarding origins and evolution of life.
ER  -

JIANG, LY, P DZIEDZIC, Zdeněk SPÁČIL, GL ZHAO, L NILSSON, LL ILAG a A CORDOVA. Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions. \textit{Scientific Reports}. LONDON: NATURE PUBLISHING GROUP, 2014, roč.~4, 6 s. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep06769.

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