Association of interleukin-8 gene variability with recurrent
aphthous stomatitis

a 2017

Association of interleukin-8 gene variability with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Denisa KAVŘÍKOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ et. al.

Základní údaje

Originální název

Association of interleukin-8 gene variability with recurrent aphthous stomatitis

Autoři

SLEZÁKOVÁ, Simona (203 Česká republika, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Denisa KAVŘÍKOVÁ (203 Česká republika, domácí), Jiřina BÁRTOVÁ (203 Česká republika), Jitka PETANOVÁ (203 Česká republika), Pavel KUKLÍNEK (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant, domácí)

Vydání

The Biomania Student Scientific Meeting 2017, Brno, 2017

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/17:00100727

Organizační jednotka

Lékařská fakulta

ISBN

978-80-210-8737-8

Klíčová slova anglicky

interleukin-8; association studies; polymorphism; recurrent aphthous stomatitis

Změněno: 18. 1. 2019 14:12, Mgr. et Mgr. Simona Slezáková, Ph.D.

Anotace

V originále

Objectives: Variability in the interleukin-8 gene (IL-8), encoding a proinflammatory chemokine, was recently associated with Behçet's syndrome, disease with recurrent oral ulcers as one of its symptoms. The aim of this study was to analyse four single nucleotide polymorphisms (SNPs) in IL-8 and its receptor 2 (CXCR2) in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Methods: Totally, 238 subjects were enrolled in this case-control study: 64 patients with RAS and 174 healthy controls were genotyped for SNPs in IL-8 (-251A/T, +396T/G, +781C/T) and CXCR2 (+1208C/T) by a method based on PCR using 5´ nuclease TaqMan assays. Results: The allele and genotype frequencies of studied polymorphisms between RAS patients and healthy controls were similar, with the exception of statistically significant differences in IL-8 +781 TT vs. CC+CT genotype frequencies between both groups. However, IL-8 A(-251)/G(+396)/C(+781) haplotype was significantly more frequent in patients with RAS (P<0.02; OR=4.2; 95% CI=1.3-13.8) than in healthy controls. Conclusions: Our study indicates that the IL-8 gene variability may affect susceptibility to RAS in the Czech population.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/0948/2016, interní kód MU

Název: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masarykova univerzita, Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV15-29336A, projekt VaV

Název: Změny imunologické reaktivity u pacientů s recidivujícími aftami

Citovat

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Denisa KAVŘÍKOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Association of interleukin-8 gene variability with recurrent aphthous stomatitis. In The Biomania Student Scientific Meeting 2017, Brno. 2017. ISBN 978-80-210-8737-8.

@proceedings{1391539,
   author = {Slezáková, Simona and Bořilová Linhartová, Petra and Kavříková, Denisa and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie},
   booktitle = {The Biomania Student Scientific Meeting 2017, Brno},
   keywords = {interleukin-8; association studies; polymorphism; recurrent aphthous stomatitis},
   language = {eng},
   isbn = {978-80-210-8737-8},
   title = {Association of interleukin-8 gene variability with recurrent aphthous stomatitis},
   year = {2017}
}

TY  - CONF
ID  - 1391539
AU  - Slezáková, Simona - Bořilová Linhartová, Petra - Kavříková, Denisa - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY  - 2017
TI  - Association of interleukin-8 gene variability with recurrent aphthous stomatitis
SN  - 9788021087378
KW  - interleukin-8
KW  - association studies
KW  - polymorphism
KW  - recurrent aphthous stomatitis
N2  - Objectives: Variability in the interleukin-8 gene (IL-8), encoding a proinflammatory chemokine, was recently associated with Behçet's syndrome, disease with recurrent oral ulcers as one of its symptoms. The aim of this study was to analyse four single nucleotide polymorphisms (SNPs) in IL-8 and its receptor 2 (CXCR2) in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Methods: Totally, 238 subjects were enrolled in this case-control study: 64 patients with RAS and 174 healthy controls were genotyped for SNPs in IL-8 (-251A/T, +396T/G, +781C/T) and CXCR2 (+1208C/T) by a method based on PCR using 5´ nuclease TaqMan assays. Results: The allele and genotype frequencies of studied polymorphisms between RAS patients and healthy controls were similar, with the exception of statistically significant differences in IL-8 +781 TT vs. CC+CT genotype frequencies between both groups. However, IL-8 A(-251)/G(+396)/C(+781) haplotype was significantly more frequent in patients with RAS (P<0.02; OR=4.2; 95% CI=1.3-13.8) than in healthy controls. Conclusions: Our study indicates that the IL-8 gene variability may affect susceptibility to RAS in the Czech population.
ER  -

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Denisa KAVŘÍKOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Association of interleukin-8 gene variability with recurrent aphthous stomatitis. In \textit{The Biomania Student Scientific Meeting 2017, Brno}. 2017. ISBN~978-80-210-8737-8.

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