| HYLSE, Ondřej, Lukáš MAIER, Roman KUČERA, Tomáš PEREČKO, Aneta SVOBODOVÁ, Lukáš KUBALA, Kamil PARUCH a Jakub ŠVENDA. A Concise Synthesis of Forskolin. Angewandte Chemie International Edition. Německo: Verlag Chemie, 2017, roč. 2017, č. 56, s. 12586-12589. ISSN 1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201706809. |
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@article{1392287,
author = {Hylse, Ondřej and Maier, Lukáš and Kučera, Roman and Perečko, Tomáš and Svobodová, Aneta and Kubala, Lukáš and Paruch, Kamil and Švenda, Jakub},
article_location = {Německo},
article_number = {56},
doi = {http://dx.doi.org/10.1002/anie.201706809},
keywords = {adenylyl cyclases; forskolin; natural product synthesis; structural analogues},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {A Concise Synthesis of Forskolin},
volume = {2017},
year = {2017}
}
TY - JOUR
ID - 1392287
AU - Hylse, Ondřej - Maier, Lukáš - Kučera, Roman - Perečko, Tomáš - Svobodová, Aneta - Kubala, Lukáš - Paruch, Kamil - Švenda, Jakub
PY - 2017
TI - A Concise Synthesis of Forskolin
JF - Angewandte Chemie International Edition
VL - 2017
IS - 56
SP - 12586-12589
EP - 12586-12589
PB - Verlag Chemie
SN - 14337851
KW - adenylyl cyclases
KW - forskolin
KW - natural product synthesis
KW - structural analogues
N2 - A 24-step synthesis of (:)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acidmodified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
ER -
HYLSE, Ondřej, Lukáš MAIER, Roman KUČERA, Tomáš PEREČKO, Aneta SVOBODOVÁ, Lukáš KUBALA, Kamil PARUCH a Jakub ŠVENDA. A Concise Synthesis of Forskolin. \textit{Angewandte Chemie International Edition}. Německo: Verlag Chemie, 2017, roč.~2017, č.~56, s.~12586-12589. ISSN~1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201706809.
|
