| KANTOROVÁ, Barbara, Jitka MALČÍKOVÁ, Kamila STRÁNSKÁ, Marek BORSKY, Karla PLEVOVÁ, Jana SMARDOVA, Lenka RADOVÁ, Nikola TOM, Martin TRBUSEK, Eva DIVISKOVA, Hana FRANCOVA SKUHROVA, Veronika NAVRKALOVÁ, Michael DOUBEK, Yvona BRYCHTOVA, Jiří MAYER a Šárka POSPÍŠILOVÁ. Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients. British journal of haematology. Hoboken: Wiley, 2017, roč. 178, č. 6, s. 979-982. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.14176. |
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@article{1393526,
author = {Kantorová, Barbara and Malčíková, Jitka and Stránská, Kamila and Borsky, Marek and Plevová, Karla and Smardova, Jana and Radová, Lenka and Tom, Nikola and Trbusek, Martin and Diviskova, Eva and Francova Skuhrova, Hana and Navrkalová, Veronika and Doubek, Michael and Brychtova, Yvona and Mayer, Jiří and Pospíšilová, Šárka},
article_location = {Hoboken},
article_number = {6},
doi = {http://dx.doi.org/10.1111/bjh.14176},
keywords = {EVOLUTION; HETEROGENEITY; CLL},
language = {eng},
issn = {0007-1048},
journal = {British journal of haematology},
title = {Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients},
url = {http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03},
volume = {178},
year = {2017}
}
TY - JOUR
ID - 1393526
AU - Kantorová, Barbara - Malčíková, Jitka - Stránská, Kamila - Borsky, Marek - Plevová, Karla - Smardova, Jana - Radová, Lenka - Tom, Nikola - Trbusek, Martin - Diviskova, Eva - Francova Skuhrova, Hana - Navrkalová, Veronika - Doubek, Michael - Brychtova, Yvona - Mayer, Jiří - Pospíšilová, Šárka
PY - 2017
TI - Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients
JF - British journal of haematology
VL - 178
IS - 6
SP - 979-982
EP - 979-982
PB - Wiley
SN - 00071048
KW - EVOLUTION
KW - HETEROGENEITY
KW - CLL
UR - http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03
L2 - http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03
N2 - The clinical course in chronic lymphocytic leukaemia (CLL) patients is diverse, reflecting the heterogeneous biological background of this disease (Guieze & Wu, 2015). Among reported defects, mutations in NOTCH1 and TP53 genes represent potent CLL progression drivers and contribute to disease chemo-refractoriness (Fabbri et al, 2011; Malcikova et al, 2015). Although parallel occurrence of NOTCH1 mutations and TP53 defects has been noted in CLL patients (Weissmann et al, 2013; Stilgenbauer et al, 2014), the clonal composition of these coexisting aberrations has not been yet studied. To clarify this phenomenon, we examined CLL patients with concurrently detected hotspot NOTCH1 and TP53 mutations using single cell analysis.
ER -
KANTOROVÁ, Barbara, Jitka MALČÍKOVÁ, Kamila STRÁNSKÁ, Marek BORSKY, Karla PLEVOVÁ, Jana SMARDOVA, Lenka RADOVÁ, Nikola TOM, Martin TRBUSEK, Eva DIVISKOVA, Hana FRANCOVA SKUHROVA, Veronika NAVRKALOVÁ, Michael DOUBEK, Yvona BRYCHTOVA, Jiří MAYER a Šárka POSPÍŠILOVÁ. Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients. \textit{British journal of haematology}. Hoboken: Wiley, 2017, roč.~178, č.~6, s.~979-982. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.14176.
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