HOFER, M., Z. HOFEROVA, Ladislav DUŠEK, Karel SOUČEK a A. GRUZDEV. Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice. Physiological research. Praha: Fyziologický ústav AV ČR, 2017, roč. 66, č. 4, s. 673-676. ISSN 0862-8408. |
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@article{1394341, author = {Hofer, M. and Hoferova, Z. and Dušek, Ladislav and Souček, Karel and Gruzdev, A.}, article_location = {Praha}, article_number = {4}, keywords = {Cyclooxygenase-2; COX-2 knock-out mice; Hematopoiesis; Ionizing radiation; Post-irradiation inflammation}, language = {eng}, issn = {0862-8408}, journal = {Physiological research}, title = {Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice}, volume = {66}, year = {2017} }
TY - JOUR ID - 1394341 AU - Hofer, M. - Hoferova, Z. - Dušek, Ladislav - Souček, Karel - Gruzdev, A. PY - 2017 TI - Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice JF - Physiological research VL - 66 IS - 4 SP - 673-676 EP - 673-676 PB - Fyziologický ústav AV ČR SN - 08628408 KW - Cyclooxygenase-2 KW - COX-2 knock-out mice KW - Hematopoiesis KW - Ionizing radiation KW - Post-irradiation inflammation N2 - We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure. ER -
HOFER, M., Z. HOFEROVA, Ladislav DUŠEK, Karel SOUČEK a A. GRUZDEV. Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2017, roč.~66, č.~4, s.~673-676. ISSN~0862-8408.
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