A head-to-head comparison of 4-L polyethylene glycol and
low-volume solutions before colonoscopy: which is the best? A
multicentre, randomized trial

J 2017

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA et. al.

Základní údaje

Originální název

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

Autoři

KOJECKÝ, Vladimír (203 Česká republika), J. MATOUS (203 Česká republika), R. KEIL (203 Česká republika), Milan DASTYCH (203 Česká republika, garant, domácí), Radek KROUPA (203 Česká republika, domácí), Z. ZADOROVA (203 Česká republika), M. VARGA (203 Česká republika), Jiří DOLINA (203 Česká republika, domácí), M. KMENT (203 Česká republika) a Aleš HEP (203 Česká republika, domácí)

Vydání

International Journal of Colorectal Disease, New York, Springer, 2017, 0179-1958

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.533

Kód RIV

RIV/00216224:14110/17:00098392

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00384-017-2901-x

UT WoS

000415692100014

Klíčová slova anglicky

Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 3. 2018 17:06, Soňa Böhmová

Anotace

V originále

Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.

Citovat

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA, Z. ZADOROVA, M. VARGA, Jiří DOLINA, M. KMENT a Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. International Journal of Colorectal Disease. New York: Springer, 2017, roč. 32, č. 12, s. 1763-1766. ISSN 0179-1958. Dostupné z: https://dx.doi.org/10.1007/s00384-017-2901-x.

@article{1396180,
   author = {Kojecký, Vladimír and Matous, J. and Keil, R. and Dastych, Milan and Kroupa, Radek and Zadorova, Z. and Varga, M. and Dolina, Jiří and Kment, M. and Hep, Aleš},
   article_location = {New York},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00384-017-2901-x},
   keywords = {Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1396180
AU  - Kojecký, Vladimír - Matous, J. - Keil, R. - Dastych, Milan - Kroupa, Radek - Zadorova, Z. - Varga, M. - Dolina, Jiří - Kment, M. - Hep, Aleš
PY  - 2017
TI  - A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial
JF  - International Journal of Colorectal Disease
VL  - 32
IS  - 12
SP  - 1763-1766
EP  - 1763-1766
PB  - Springer
SN  - 01791958
KW  - Ascorbic acid
KW  - Colonoscopy
KW  - Magnesium citrate
KW  - Picosulfate sodium
KW  - Polyethylene glycol
N2  - Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.
ER  -

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA, Z. ZADOROVA, M. VARGA, Jiří DOLINA, M. KMENT a Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. \textit{International Journal of Colorectal Disease}. New York: Springer, 2017, roč.~32, č.~12, s.~1763-1766. ISSN~0179-1958. Dostupné z: https://dx.doi.org/10.1007/s00384-017-2901-x.

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