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@article{1396476,
author = {Fathalla, Walid and Pazdera, Pavel},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s11696-017-0273-x},
keywords = {Amino acid esters; Chemoselective reactions; Intramolecular hydrogen bond; Domino reaction},
language = {eng},
issn = {2585-7290},
journal = {Chemical Papers},
title = {Domino synthesis of quinazolin-4-yl thioureido alkanoates},
url = {https://doi.org/10.1007/s11696-017-0273-x},
volume = {72},
year = {2018}
}
TY - JOUR
ID - 1396476
AU - Fathalla, Walid - Pazdera, Pavel
PY - 2018
TI - Domino synthesis of quinazolin-4-yl thioureido alkanoates
JF - Chemical Papers
VL - 72
IS - 1
SP - 209-219
EP - 209-219
PB - Springer
SN - 25857290
KW - Amino acid esters
KW - Chemoselective reactions
KW - Intramolecular hydrogen bond
KW - Domino reaction
UR - https://doi.org/10.1007/s11696-017-0273-x
L2 - https://doi.org/10.1007/s11696-017-0273-x
N2 - A simple convenient protocol for the synthesis of Me 2-[3-(2-(substituted phenyl)quinazolin-4-yl)thioureido] alkanoates I (R1 = H, CH3, OCH3; R2 = H, OCH3; R3 = H, CH3; R4 = H, CH3, CH2CH(CH3)2, C6H5; n = 0, 1, 2) has been described. It involves the domino reaction of various amino acid esters NH2CHR4(CH2)nC(O)OCH3·HCl with imidoylisothiocyanates II in Et acetate to afford quinazoline thiourea derivs. in excellent yields. Short reaction time, mild condition, simple work up, high yields, and pure products are the major advantages of this protocol. The no. of isolated pure compds. from this simple protocol is 24. The starting imidoyl isothiocyanates II were prepd. from the corresponding benzanilides III and purified by flash chromatog.
ER -
FATHALLA, Walid a Pavel PAZDERA. Domino synthesis of quinazolin-4-yl thioureido alkanoates. \textit{Chemical Papers}. Springer, 2018, roč.~72, č.~1, s.~209-219. ISSN~2585-7290. Dostupné z: https://dx.doi.org/10.1007/s11696-017-0273-x.
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