The burden and epidemiology of community-acquired central nervous system infections: a multinational study
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ERDEM, Hakan; A. INAN; E. GUVEN; S. HARGREAVES; L. LARSEN; G. SHEHATA; Eva PERNICOVÁ; E. KHAN; Lenka BAŠTÁKOVÁ; S. NAMANI; A. HARXHI; T. ROGANOVIC; B. LAKATOS; S. UYSAL; O. R. SIPAHI; A. CRISAN; E. MIFTODE; Roman STEBEL ORCID; B. JEGOROVIC; Z. FEHER; C. JEKKEL; N. PANDAK; A. MORAVVEJI; H. YILMAZ; A. KHALIFA; U. MUSABAK; S. YILMAZ; A. JOUHAR; N. OZTOPRAK; X. ARGEMI; M. BALDEYROU; G. BELLAUD; R. V. MOROTI; R. HASBUN; L. SALAZAR; R. TEKIN; A. CANESTRI; L. CALKIC; L. PRATICO; F. YILMAZ-KARADAG; L. SANTOS; A. PINTO; F. KAPTAN; P. BOSSI; J. ARON; A. DUISSENOVA; G. SHOPAYEVA; B. UTAGANOV; S. GRGIC; G. ERSOZ; A. K. L. WU; K. C. LUNG; A. BRUZSA; L. B. RADIC; H. KAHRAMAN; M. MOMEN-HERAVI; S. KULZHANOVA; F. RIGO; M. KONKAYEVA; Z. SMAGULOVA; T. TANG; P. CHAN; S. AHMETAGIC; H. POROBIC-JAHIC; F. MORADI; S. KAYA; Y. CAG; A. BOHR; C. ARTUK; I. CELIK; M. AMSILLI; H. C. GUL; A. CASCIO; M. LANZAFAME a M. NASSAR
Vydání
European Journal of Clinical Microbiology & Infectious Diseases, New York, Springer, 2017, 0934-9723
Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
ERDEM, Hakan; A. INAN; E. GUVEN; S. HARGREAVES; L. LARSEN; G. SHEHATA; Eva PERNICOVÁ; E. KHAN; Lenka BAŠTÁKOVÁ; S. NAMANI; A. HARXHI; T. ROGANOVIC; B. LAKATOS; S. UYSAL; O. R. SIPAHI; A. CRISAN; E. MIFTODE; Roman STEBEL; B. JEGOROVIC; Z. FEHER; C. JEKKEL; N. PANDAK; A. MORAVVEJI; H. YILMAZ; A. KHALIFA; U. MUSABAK; S. YILMAZ; A. JOUHAR; N. OZTOPRAK; X. ARGEMI; M. BALDEYROU; G. BELLAUD; R. V. MOROTI; R. HASBUN; L. SALAZAR; R. TEKIN; A. CANESTRI; L. CALKIC; L. PRATICO; F. YILMAZ-KARADAG; L. SANTOS; A. PINTO; F. KAPTAN; P. BOSSI; J. ARON; A. DUISSENOVA; G. SHOPAYEVA; B. UTAGANOV; S. GRGIC; G. ERSOZ; A. K. L. WU; K. C. LUNG; A. BRUZSA; L. B. RADIC; H. KAHRAMAN; M. MOMEN-HERAVI; S. KULZHANOVA; F. RIGO; M. KONKAYEVA; Z. SMAGULOVA; T. TANG; P. CHAN; S. AHMETAGIC; H. POROBIC-JAHIC; F. MORADI; S. KAYA; Y. CAG; A. BOHR; C. ARTUK; I. CELIK; M. AMSILLI; H. C. GUL; A. CASCIO; M. LANZAFAME a M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. European Journal of Clinical Microbiology & Infectious Diseases. New York: Springer, 2017, roč. 36, č. 9, s. 1595-1611. ISSN 0934-9723. Dostupné z: https://doi.org/10.1007/s10096-017-2973-0.
@article{1397293, author = {Erdem, Hakan and Inan, A. and Guven, E. and Hargreaves, S. and Larsen, L. and Shehata, G. and Pernicová, Eva and Khan, E. and Baštáková, Lenka and Namani, S. and Harxhi, A. and Roganovic, T. and Lakatos, B. and Uysal, S. and Sipahi, O. R. and Crisan, A. and Miftode, E. and Stebel, Roman and Jegorovic, B. and Feher, Z. and Jekkel, C. and Pandak, N. and Moravveji, A. and Yilmaz, H. and Khalifa, A. and Musabak, U. and Yilmaz, S. and Jouhar, A. and Oztoprak, N. and Argemi, X. and Baldeyrou, M. and Bellaud, G. and Moroti, R. V. and Hasbun, R. and Salazar, L. and Tekin, R. and Canestri, A. and Calkic, L. and Pratico, L. and YilmazandKaradag, F. and Santos, L. and Pinto, A. and Kaptan, F. and Bossi, P. and Aron, J. and Duissenova, A. and Shopayeva, G. and Utaganov, B. and Grgic, S. and Ersoz, G. and Wu, A. K. L. and Lung, K. C. and Bruzsa, A. and Radic, L. B. and Kahraman, H. and MomenandHeravi, M. and Kulzhanova, S. and Rigo, F. and Konkayeva, M. and Smagulova, Z. and Tang, T. and Chan, P. and Ahmetagic, S. and PorobicandJahic, H. and Moradi, F. and Kaya, S. and Cag, Y. and Bohr, A. and Artuk, C. and Celik, I. and Amsilli, M. and Gul, H. C. and Cascio, A. and Lanzafame, M. and Nassar, M.}, article_location = {New York}, article_number = {9}, doi = {https://doi.org/10.1007/s10096-017-2973-0}, keywords = {Central nervous system infections; Epidemiology; Streptococcus pneumoniae; Neurosyphilis; Neuroborreliosis; CNS tuberculosis}, language = {eng}, issn = {0934-9723}, journal = {European Journal of Clinical Microbiology & Infectious Diseases}, title = {The burden and epidemiology of community-acquired central nervous system infections: a multinational study}, url = {https://link.springer.com/article/10.1007%2Fs10096-017-2973-0}, volume = {36}, year = {2017} }
TY - JOUR ID - 1397293 AU - Erdem, Hakan - Inan, A. - Guven, E. - Hargreaves, S. - Larsen, L. - Shehata, G. - Pernicová, Eva - Khan, E. - Baštáková, Lenka - Namani, S. - Harxhi, A. - Roganovic, T. - Lakatos, B. - Uysal, S. - Sipahi, O. R. - Crisan, A. - Miftode, E. - Stebel, Roman - Jegorovic, B. - Feher, Z. - Jekkel, C. - Pandak, N. - Moravveji, A. - Yilmaz, H. - Khalifa, A. - Musabak, U. - Yilmaz, S. - Jouhar, A. - Oztoprak, N. - Argemi, X. - Baldeyrou, M. - Bellaud, G. - Moroti, R. V. - Hasbun, R. - Salazar, L. - Tekin, R. - Canestri, A. - Calkic, L. - Pratico, L. - Yilmaz-Karadag, F. - Santos, L. - Pinto, A. - Kaptan, F. - Bossi, P. - Aron, J. - Duissenova, A. - Shopayeva, G. - Utaganov, B. - Grgic, S. - Ersoz, G. - Wu, A. K. L. - Lung, K. C. - Bruzsa, A. - Radic, L. B. - Kahraman, H. - Momen-Heravi, M. - Kulzhanova, S. - Rigo, F. - Konkayeva, M. - Smagulova, Z. - Tang, T. - Chan, P. - Ahmetagic, S. - Porobic-Jahic, H. - Moradi, F. - Kaya, S. - Cag, Y. - Bohr, A. - Artuk, C. - Celik, I. - Amsilli, M. - Gul, H. C. - Cascio, A. - Lanzafame, M. - Nassar, M. PY - 2017 TI - The burden and epidemiology of community-acquired central nervous system infections: a multinational study JF - European Journal of Clinical Microbiology & Infectious Diseases VL - 36 IS - 9 SP - 1595-1611 EP - 1595-1611 PB - Springer SN - 09349723 KW - Central nervous system infections KW - Epidemiology KW - Streptococcus pneumoniae KW - Neurosyphilis KW - Neuroborreliosis KW - CNS tuberculosis UR - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0 L2 - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0 N2 - Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity. ER -
ERDEM, Hakan; A. INAN; E. GUVEN; S. HARGREAVES; L. LARSEN; G. SHEHATA; Eva PERNICOVÁ; E. KHAN; Lenka BAŠTÁKOVÁ; S. NAMANI; A. HARXHI; T. ROGANOVIC; B. LAKATOS; S. UYSAL; O. R. SIPAHI; A. CRISAN; E. MIFTODE; Roman STEBEL; B. JEGOROVIC; Z. FEHER; C. JEKKEL; N. PANDAK; A. MORAVVEJI; H. YILMAZ; A. KHALIFA; U. MUSABAK; S. YILMAZ; A. JOUHAR; N. OZTOPRAK; X. ARGEMI; M. BALDEYROU; G. BELLAUD; R. V. MOROTI; R. HASBUN; L. SALAZAR; R. TEKIN; A. CANESTRI; L. CALKIC; L. PRATICO; F. YILMAZ-KARADAG; L. SANTOS; A. PINTO; F. KAPTAN; P. BOSSI; J. ARON; A. DUISSENOVA; G. SHOPAYEVA; B. UTAGANOV; S. GRGIC; G. ERSOZ; A. K. L. WU; K. C. LUNG; A. BRUZSA; L. B. RADIC; H. KAHRAMAN; M. MOMEN-HERAVI; S. KULZHANOVA; F. RIGO; M. KONKAYEVA; Z. SMAGULOVA; T. TANG; P. CHAN; S. AHMETAGIC; H. POROBIC-JAHIC; F. MORADI; S. KAYA; Y. CAG; A. BOHR; C. ARTUK; I. CELIK; M. AMSILLI; H. C. GUL; A. CASCIO; M. LANZAFAME a M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. \textit{European Journal of Clinical Microbiology \&{} Infectious Diseases}. New York: Springer, 2017, roč.~36, č.~9, s.~1595-1611. ISSN~0934-9723. Dostupné z: https://doi.org/10.1007/s10096-017-2973-0.