Blood level of CD45+platelets and development of restenosis
after drug-eluting stent implantation in patients with stable
coronary artery disease

J 2016

Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease

GABBASOV, Z.; S. KOZLOV; S. BYAZROVA; O. SABUROVA; I. MELNIKOV et al.

Základní údaje

Originální název

Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease

Autoři

GABBASOV, Z.; S. KOZLOV; S. BYAZROVA; O. SABUROVA; I. MELNIKOV; M. CAPRNDA; E. CURILLA; L. GASPAR; Peter KRUŽLIAK a V. SMIRNOV

Vydání

Wiener klinische Wochenschrift, Vídeň, SPRINGER WIEN, 2016, 0043-5325

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.974

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00098628

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Coronary artery disease; Drug-eluting stents; Restenosis; CD45+platelets; Inflammation

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 12. 2017 10:48, Soňa Böhmová

Anotace

V originále

The aim of this study was to assess CD45-positive platelets (CD45+ platelets) involvement in restenosis development after drug-eluting stent (DES) implantation in patients with stable coronary artery disease (CAD). The study comprised 126 male and female patients with stable angina pectoris, who underwent elective coronary stenting with DES and follow-up angiography within 6-12 months. The patients were assigned to the group with restenosis (n = 53) or group without restenosis (n = 73) according to the follow-up angiograms. In both groups we compared the level in blood of CD45+ platelets, the clinical, laboratory and angiographic variables, which may affect the development of restenosis. We have also constructed a logit regression model for prognosis of restenosis occurrence after DES implantation. The blood count of CD45+ platelets was higher in patients with restenosis than in patients without: 0.82 % (0.58; 1.12) vs. 0.34 % (0.20; 0.68), p < 0.001, data are expressed as median (lower quartile; upper quartile). By binary comparisons of more than 35 different clinical, laboratory and angiographic variables we identified 8 significant risk factors for the development of stent restenosis after DES. In order to define the risk of the development of restenosis, we have built a logit regression model. The resulting logit regression equation included the level of CD45+ platelets, the neutrophil to lymphocyte ratio (NLR), small diameter arteries stenting and the number of simultaneously implanted stents in one patient. Receiver operating characteristic (ROC) curve analysis has demonstrated the high prognostic value of the resulting logit regression equation with an area under the curve (AUC) of 0.91 % (p < 0.001). The acquired data indicate the presence of a close relationship between circulating CD45+ platelets and restenosis development after DES implantation in patients with stable CAD.

Citovat

GABBASOV, Z.; S. KOZLOV; S. BYAZROVA; O. SABUROVA; I. MELNIKOV; M. CAPRNDA; E. CURILLA; L. GASPAR; Peter KRUŽLIAK a V. SMIRNOV. Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease. Wiener klinische Wochenschrift. Vídeň: SPRINGER WIEN, 2016, roč. 128, 23-24, s. 898-905. ISSN 0043-5325. Dostupné z: https://doi.org/10.1007/s00508-016-1074-x.

@article{1398260,
   author = {Gabbasov, Z. and Kozlov, S. and Byazrova, S. and Saburova, O. and Melnikov, I. and Caprnda, M. and Curilla, E. and Gaspar, L. and Kružliak, Peter and Smirnov, V.},
   article_location = {Vídeň},
   article_number = {23-24},
   doi = {https://doi.org/10.1007/s00508-016-1074-x},
   keywords = {Coronary artery disease; Drug-eluting stents; Restenosis; CD45+platelets; Inflammation},
   language = {eng},
   issn = {0043-5325},
   journal = {Wiener klinische Wochenschrift},
   title = {Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease},
   volume = {128},
   year = {2016}
}

TY  - JOUR
ID  - 1398260
AU  - Gabbasov, Z. - Kozlov, S. - Byazrova, S. - Saburova, O. - Melnikov, I. - Caprnda, M. - Curilla, E. - Gaspar, L. - Kružliak, Peter - Smirnov, V.
PY  - 2016
TI  - Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease
JF  - Wiener klinische Wochenschrift
VL  - 128
IS  - 23-24
SP  - 898-905
EP  - 898-905
PB  - SPRINGER WIEN
SN  - 00435325
KW  - Coronary artery disease
KW  - Drug-eluting stents
KW  - Restenosis
KW  - CD45+platelets
KW  - Inflammation
N2  - The aim of this study was to assess CD45-positive platelets (CD45+ platelets) involvement in restenosis development after drug-eluting stent (DES) implantation in patients with stable coronary artery disease (CAD). The study comprised 126 male and female patients with stable angina pectoris, who underwent elective coronary stenting with DES and follow-up angiography within 6-12 months. The patients were assigned to the group with restenosis (n = 53) or group without restenosis (n = 73) according to the follow-up angiograms. In both groups we compared the level in blood of CD45+ platelets, the clinical, laboratory and angiographic variables, which may affect the development of restenosis. We have also constructed a logit regression model for prognosis of restenosis occurrence after DES implantation. The blood count of CD45+ platelets was higher in patients with restenosis than in patients without: 0.82 % (0.58; 1.12) vs. 0.34 % (0.20; 0.68), p < 0.001, data are expressed as median (lower quartile; upper quartile). By binary comparisons of more than 35 different clinical, laboratory and angiographic variables we identified 8 significant risk factors for the development of stent restenosis after DES. In order to define the risk of the development of restenosis, we have built a logit regression model. The resulting logit regression equation included the level of CD45+ platelets, the neutrophil to lymphocyte ratio (NLR), small diameter arteries stenting and the number of simultaneously implanted stents in one patient. Receiver operating characteristic (ROC) curve analysis has demonstrated the high prognostic value of the resulting logit regression equation with an area under the curve (AUC) of 0.91 % (p < 0.001). The acquired data indicate the presence of a close relationship between circulating CD45+ platelets and restenosis development after DES implantation in patients with stable CAD.
ER  -

GABBASOV, Z.; S. KOZLOV; S. BYAZROVA; O. SABUROVA; I. MELNIKOV; M. CAPRNDA; E. CURILLA; L. GASPAR; Peter KRUŽLIAK a V. SMIRNOV. Blood level of CD45+platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease. \textit{Wiener klinische Wochenschrift}. Vídeň: SPRINGER WIEN, 2016, roč.~128, 23-24, s.~898-905. ISSN~0043-5325. Dostupné z: https://doi.org/10.1007/s00508-016-1074-x.

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