Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic
Consequences of the Warburg Effect

J 2017

Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA et. al.

Základní údaje

Originální název

Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect

Autoři

SALAMON, S. (705 Slovinsko), E. PODBREGAR (705 Slovinsko), P. KUBATKA (703 Slovensko), D. BUSSELBERG (634 Katar), M. CAPRNDA (703 Slovensko), R. OPATRILOVA (203 Česká republika), V. VALENTOVA (703 Slovensko), M. ADAMEK (703 Slovensko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a M. PODBREGAR (705 Slovinsko)

Vydání

Nutrition and cancer : an international journal, Abingdon, Routledge Journals, Taylor & Francis, 2017, 0163-5581

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.261

Kód RIV

RIV/00216224:14110/17:00098632

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1080/01635581.2017.1263751

UT WoS

000394613600001

Klíčová slova anglicky

Glucose Metabolism

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 18:49, Soňa Böhmová

Anotace

V originále

The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?

Citovat

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK a M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. Nutrition and cancer : an international journal. Abingdon: Routledge Journals, Taylor & Francis, 2017, roč. 69, č. 2, s. 177-183. ISSN 0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2017.1263751.

@article{1398264,
   author = {Salamon, S. and Podbregar, E. and Kubatka, P. and Busselberg, D. and Caprnda, M. and Opatrilova, R. and Valentova, V. and Adamek, M. and Kružliak, Peter and Podbregar, M.},
   article_location = {Abingdon},
   article_number = {2},
   doi = {http://dx.doi.org/10.1080/01635581.2017.1263751},
   keywords = {Glucose Metabolism},
   language = {eng},
   issn = {0163-5581},
   journal = {Nutrition and cancer : an international journal},
   title = {Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect},
   volume = {69},
   year = {2017}
}

TY  - JOUR
ID  - 1398264
AU  - Salamon, S. - Podbregar, E. - Kubatka, P. - Busselberg, D. - Caprnda, M. - Opatrilova, R. - Valentova, V. - Adamek, M. - Kružliak, Peter - Podbregar, M.
PY  - 2017
TI  - Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
JF  - Nutrition and cancer : an international journal
VL  - 69
IS  - 2
SP  - 177-183
EP  - 177-183
PB  - Routledge Journals, Taylor & Francis
SN  - 01635581
KW  - Glucose Metabolism
N2  - The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?
ER  -

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK a M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. \textit{Nutrition and cancer : an international journal}. Abingdon: Routledge Journals, Taylor \&{} Francis, 2017, roč.~69, č.~2, s.~177-183. ISSN~0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2017.1263751.

Podrobný výpis o publikaci