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@article{1400993,
author = {Addario, D. and Micale, Vincenzo and Di Bartolomeo, M. and Štark, Tibor and Pucci, M. and Šulcová, Alexandra and Palazzo, M. and Babinská, Zuzana and Cremaschi, L. and Drago, F. and Altamura, C.A. and Maccarrone, M. and Dell'Osso, B.},
article_location = {AMSTERDAM},
article_number = {OCT 2017},
doi = {http://dx.doi.org/10.1016/j.schres.2017.01.022},
keywords = {Endocannabinoid system (ECS); Cannabinoid receptor type-1; DNA methylation; Schizophrenia; Methylazoxymethanol (MAM) rat model},
language = {eng},
issn = {0920-9964},
journal = {Schizophrenia Research},
title = {A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia},
volume = {188},
year = {2017}
}
TY - JOUR
ID - 1400993
AU - Addario, D. - Micale, Vincenzo - Di Bartolomeo, M. - Štark, Tibor - Pucci, M. - Šulcová, Alexandra - Palazzo, M. - Babinská, Zuzana - Cremaschi, L. - Drago, F. - Altamura, C.A. - Maccarrone, M. - Dell'Osso, B.
PY - 2017
TI - A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia
JF - Schizophrenia Research
VL - 188
IS - OCT 2017
SP - 132-140
EP - 132-140
PB - ELSEVIER SCIENCE BV
SN - 09209964
KW - Endocannabinoid system (ECS)
KW - Cannabinoid receptor type-1
KW - DNA methylation
KW - Schizophrenia
KW - Methylazoxymethanol (MAM) rat model
N2 - Compelling evidence supports the involvement of the endocannabinoid system(ECS) in psychosis vulnerability. We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subjects suffering from bipolar disorder, major depressive disorder and schizophrenia, focusing in particular on the effects of DNA methylation. We observed selective alterations of DNA methylation at the promoter of CNR1, the gene coding for the type-1 cannabinoid receptor, in schizophrenic patients (N = 25) with no changes in any other disorder. We confirmed the regulation of CNR1 in a well-validated animal model of schizophrenia, induced by prenatal methylazoxymethanol (MAM) acetate exposure (N = 7 per group) where we found, in the prefrontal cortex, a significant increase in CNR1 expression and a consistent reduction in DNA methylation at specific CpG sites of gene promoter. Overall, our findings suggest a selective dysregulation of ECS in psychosis, and highlight the evaluation of CNR1 DNA methylation levels in PBMCs as a potential biomarker for schizophrenia. (C) 2017 Elsevier B.V. All rights reserved.
ER -
ADDARIO, D., Vincenzo MICALE, M. DI BARTOLOMEO, Tibor ŠTARK, M. PUCCI, Alexandra ŠULCOVÁ, M. PALAZZO, Zuzana BABINSKÁ, L. CREMASCHI, F. DRAGO, C.A. ALTAMURA, M. MACCARRONE a B. DELL'OSSO. A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia. \textit{Schizophrenia Research}. AMSTERDAM: ELSEVIER SCIENCE BV, roč.~188, OCT 2017, s.~132-140. ISSN~0920-9964. doi:10.1016/j.schres.2017.01.022. 2017.
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