The Root Growth-Regulating Brevicompanine Natural Products
Modulate the Plant Circadian Clock

J 2017

The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock

MONTAIGU, A.; A. OELJEKLAUS; J. KRAHN; J.H. SULIMAN; M.N.S. HALDER et. al.

Základní údaje

Originální název

The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock

Autoři

Vydání

ACS CHEMICAL BIOLOGY, Washington D.C. AMER CHEMICAL SOC, 2017, 1554-8929

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.592

Kód RIV

RIV/00216224:14740/17:00099307

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1021/acschembio.6b00978

UT WoS

000403854000004

EID Scopus

2-s2.0-85020921485

Klíčová slova anglicky

ARABIDOPSIS-THALIANA; CHEMICAL BIOLOGY; GENES; EXPRESSION; OPPORTUNITIES; SYSTEM; AUXIN; TIME

Štítky

OA, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 3. 2018 14:49, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.

Citovat

MONTAIGU, A.; A. OELJEKLAUS; J. KRAHN; J.H. SULIMAN; M.N.S. HALDER; V. de ANSORENA; E. NICKEL; S. SCHLICHT; M. PLIHAL; O. KUBIASOVA; Lenka RADOVÁ; L. KRACHER; B. TOTH; R. KASCHANI; F. COUPLAND; G. KOMBRINK a E. KAISER. The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock. ACS CHEMICAL BIOLOGY. Washington D.C.: AMER CHEMICAL SOC, 2017, roč. 12, č. 6, s. 1466-1471. ISSN 1554-8929. Dostupné z: https://doi.org/10.1021/acschembio.6b00978.

@article{1403113,
   author = {Montaigu, A. and Oeljeklaus, A. and Krahn, J. and Suliman, J.H. and Halder, M.N.S. and Ansorena, V. de and Nickel, E. and Schlicht, S. and Plihal, M. and Kubiasova, O. and Radová, Lenka and Kracher, L. and Toth, B. and Kaschani, R. and Coupland, F. and Kombrink, G. and Kaiser, E.},
   article_location = {Washington D.C.},
   article_number = {6},
   doi = {https://doi.org/10.1021/acschembio.6b00978},
   keywords = {ARABIDOPSIS-THALIANA; CHEMICAL BIOLOGY; GENES; EXPRESSION; OPPORTUNITIES; SYSTEM; AUXIN; TIME},
   language = {eng},
   issn = {1554-8929},
   journal = {ACS CHEMICAL BIOLOGY},
   title = {The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock},
   url = {http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978},
   volume = {12},
   year = {2017}
}

TY  - JOUR
ID  - 1403113
AU  - Montaigu, A. - Oeljeklaus, A. - Krahn, J. - Suliman, J.H. - Halder, M.N.S. - Ansorena, V. de - Nickel, E. - Schlicht, S. - Plihal, M. - Kubiasova, O. - Radová, Lenka - Kracher, L. - Toth, B. - Kaschani, R. - Coupland, F. - Kombrink, G. - Kaiser, E.
PY  - 2017
TI  - The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
JF  - ACS CHEMICAL BIOLOGY
VL  - 12
IS  - 6
SP  - 1466-1471
EP  - 1466-1471
PB  - AMER CHEMICAL SOC
SN  - 15548929
KW  - ARABIDOPSIS-THALIANA
KW  - CHEMICAL BIOLOGY
KW  - GENES
KW  - EXPRESSION
KW  - OPPORTUNITIES
KW  - SYSTEM
KW  - AUXIN
KW  - TIME
UR  - http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978
L2  - http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978
N2  - Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.
ER  -

MONTAIGU, A.; A. OELJEKLAUS; J. KRAHN; J.H. SULIMAN; M.N.S. HALDER; V. de ANSORENA; E. NICKEL; S. SCHLICHT; M. PLIHAL; O. KUBIASOVA; Lenka RADOVÁ; L. KRACHER; B. TOTH; R. KASCHANI; F. COUPLAND; G. KOMBRINK a E. KAISER. The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock. \textit{ACS CHEMICAL BIOLOGY}. Washington D.C.: AMER CHEMICAL SOC, 2017, roč.~12, č.~6, s.~1466-1471. ISSN~1554-8929. Dostupné z: https://doi.org/10.1021/acschembio.6b00978.

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