2017
Influence of compression aids on baroreflex function in patients with cervical spinal cord injury
SVAČINOVÁ, Jana; Katarína ONDRUŠOVÁ; Michal JAVORKA; Marie NOVÁKOVÁ; Zuzana NOVÁKOVÁ et al.Základní údaje
Originální název
Influence of compression aids on baroreflex function in patients with cervical spinal cord injury
Název česky
Vliv kompresních pomůcek na funkci baroreflexu u pacientů s krční míšní lézí
Název anglicky
Influence of compression aids on baroreflex function in patients with cervical spinal cord injury
Autoři
Vydání
2017
Další údaje
Typ výsledku
Konferenční abstrakt
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ne
Klíčová slova česky
poranění míchy, baroreflex, krevní tlak
Klíčová slova anglicky
spinal cord injury, baroreflex, blood pressure
Změněno: 17. 1. 2018 16:36, Mgr. Bc. Jana Svačinová, Ph.D.
V originále
Introduction: Patients after cervical spinal cord injury (cSCI) often suffer from orthostatic hypotension (OH). Although vagal cardiac chronotropic effect is preserved in cSCI, baroreflex vascular tone regulation is impaired due to interrupted sympathetic pathways below the cSCI level. Patients usually use compression aids (CA, e.g. stockings, abdominal corset) to mitigate blood pressure (BP) drop during orthostasis. This study aimed to assess the influence of CA on baroreflex function in cSCI patients during orthostasis. Methods: BP was continuously recorded in 9 cSCI patients during passive orthostasis without and with CA. Beat-to-beat systolic blood pressure (SBP) and inter-beat intervals (IBI) sequences were obtained from continuous non-invasive BP recording. Pulse pressure (PP) was evaluated as a mean of beat-to-beat differences between SBP and diastolic pressures. Closed loop of SBP IBI interaction was mathematically opened by bivariate autoregressive model; causal coherence (a measure of IBI and SBP synchronization) and gain estimating baroreflex sensitivity (BRS) were calculated in baroreflex direction (from SBP to IBI). Results: When CA were applied, coherence and PP were significantly increased as compared to orthostasis without CA (p < 0.05). CA application was also associated with an increase of BRS (borderline significant; p = 0.059). Patients reported less OH symptoms when wearing CA. Conclusion: Use of CA increased venous return and consequently stroke volume expressed as an increase of PP in this study. This probably prevented the baroreflex sensitivity decrease during orthostasis. We suppose that positive influence of CA on blood pressure regulation during orthostasis weakened OH symptoms in cSCI.
Anglicky
Introduction: Patients after cervical spinal cord injury (cSCI) often suffer from orthostatic hypotension (OH). Although vagal cardiac chronotropic effect is preserved in cSCI, baroreflex vascular tone regulation is impaired due to interrupted sympathetic pathways below the cSCI level. Patients usually use compression aids (CA, e.g. stockings, abdominal corset) to mitigate blood pressure (BP) drop during orthostasis. This study aimed to assess the influence of CA on baroreflex function in cSCI patients during orthostasis. Methods: BP was continuously recorded in 9 cSCI patients during passive orthostasis without and with CA. Beat-to-beat systolic blood pressure (SBP) and inter-beat intervals (IBI) sequences were obtained from continuous non-invasive BP recording. Pulse pressure (PP) was evaluated as a mean of beat-to-beat differences between SBP and diastolic pressures. Closed loop of SBP IBI interaction was mathematically opened by bivariate autoregressive model; causal coherence (a measure of IBI and SBP synchronization) and gain estimating baroreflex sensitivity (BRS) were calculated in baroreflex direction (from SBP to IBI). Results: When CA were applied, coherence and PP were significantly increased as compared to orthostasis without CA (p < 0.05). CA application was also associated with an increase of BRS (borderline significant; p = 0.059). Patients reported less OH symptoms when wearing CA. Conclusion: Use of CA increased venous return and consequently stroke volume expressed as an increase of PP in this study. This probably prevented the baroreflex sensitivity decrease during orthostasis. We suppose that positive influence of CA on blood pressure regulation during orthostasis weakened OH symptoms in cSCI.
Návaznosti
| MUNI/A/1355/2016, interní kód MU |
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