The Effect of Haloperidol Administration on Heart Rate
Variability in Isolated Heart of Schizophrenia-like and Control
Rats

D 2017

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

JANOUŠEK, Oto; Tibor STRAČINA; Marina RONZHINA; Jakub HEJČ; Tibor ŠTARK et al.

Základní údaje

Originální název

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

Název česky

Vliv aplikace haloperidolu na variabilitu srdeční frekvence u izolovaného srdce potkanů se schizofrenním fenotypem

Autoři

JANOUŠEK, Oto; Tibor STRAČINA ; Marina RONZHINA; Jakub HEJČ; Tibor ŠTARK; Jana RUDÁ; Vincenzo MICALE; Jana KOLÁŘOVÁ; Marie NOVÁKOVÁ a Ivo PROVAZNÍK

Vydání

LOS ALAMITOS, 2017 COMPUTING IN CARDIOLOGY (CINC), od s. 1-4, 4 s. 2017

Nakladatel

IEEE Computer Society

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00100801

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova anglicky

haloperidol

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2019 14:07, Soňa Böhmová

Anotace

V originále

Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial.

Návaznosti

GAP102/12/2034, projekt VaV

Název: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor

Investor: Grantová agentura ČR, Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor

MUNI/A/1355/2016, interní kód MU

Název: Kardiovaskulární systém očima molekulární fyziologie

Investor: Masarykova univerzita, Kardiovaskulární systém očima molekulární fyziologie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1363/2016, interní kód MU

Název: Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi - prospektivní studie

Investor: Masarykova univerzita, Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi - prospektivní studie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

JANOUŠEK, Oto; Tibor STRAČINA; Marina RONZHINA; Jakub HEJČ; Tibor ŠTARK; Jana RUDÁ; Vincenzo MICALE; Jana KOLÁŘOVÁ; Marie NOVÁKOVÁ a Ivo PROVAZNÍK. The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats. In 2017 COMPUTING IN CARDIOLOGY (CINC). LOS ALAMITOS: IEEE Computer Society, 2017, s. 1-4. ISSN 0276-6574. Dostupné z: https://doi.org/10.22489/CinC.2017.150-161.

@inproceedings{1405230,
   author = {Janoušek, Oto and Stračina, Tibor and Ronzhina, Marina and Hejč, Jakub and Štark, Tibor and Rudá, Jana and Micale, Vincenzo and Kolářová, Jana and Nováková, Marie and Provazník, Ivo},
   address = {LOS ALAMITOS},
   booktitle = {2017 COMPUTING IN CARDIOLOGY (CINC)},
   doi = {https://doi.org/10.22489/CinC.2017.150-161},
   keywords = {haloperidol},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {LOS ALAMITOS},
   pages = {1-4},
   publisher = {IEEE Computer Society},
   title = {The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats},
   year = {2017}
}

TY  - CONF
ID  - 1405230
AU  - Janoušek, Oto - Stračina, Tibor - Ronzhina, Marina - Hejč, Jakub - Štark, Tibor - Rudá, Jana - Micale, Vincenzo - Kolářová, Jana - Nováková, Marie - Provazník, Ivo
PY  - 2017
TI  - The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats
PB  - IEEE Computer Society
CY  - LOS ALAMITOS
KW  - haloperidol
N2  - Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial.
ER  -

JANOUŠEK, Oto; Tibor STRAČINA; Marina RONZHINA; Jakub HEJČ; Tibor ŠTARK; Jana RUDÁ; Vincenzo MICALE; Jana KOLÁŘOVÁ; Marie NOVÁKOVÁ a Ivo PROVAZNÍK. The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats. In \textit{2017 COMPUTING IN CARDIOLOGY (CINC)}. LOS ALAMITOS: IEEE Computer Society, 2017, s.~1-4. ISSN~0276-6574. Dostupné z: https://doi.org/10.22489/CinC.2017.150-161.

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