CD36 gene polymorphism is associated with Alzheimer's disease

J 2017

CD36 gene polymorphism is associated with Alzheimer's disease

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN et. al.

Základní údaje

Originální název

CD36 gene polymorphism is associated with Alzheimer's disease

Autoři

ŠERÝ, Omar (203 Česká republika, garant, domácí), J. JANOUTOVA (203 Česká republika), Laura EWERLINGOVÁ (203 Česká republika, domácí), Alice HÁLOVÁ (203 Česká republika, domácí), Jan LOCHMAN (203 Česká republika, domácí), Vladimír JANOUT (203 Česká republika, domácí), Naim Akhtar KHAN (250 Francie) a VJ BALCAR (203 Česká republika)

Vydání

Biochimie, Paris, Elsevier France- editions Scientifiques Medicales Elsevier, 2017, 0300-9084

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.188

Kód RIV

RIV/00216224:14310/17:00095706

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.biochi.2017.01.009

UT WoS

000397694600006

Klíčová slova anglicky

Polymorphism; Association; CD36; Gene; ApoE; MMSE

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 3. 2018 23:24, Ing. Nicole Zrilić

Anotace

V originále

CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.

Návaznosti

NV16-31207A, projekt VaV

Název: Genetika a epidemiologie Alzheimerovy choroby

16-31207A, interní kód MU
(Kód CEP: NV16-31207A)

Název: Genetika a epidemiologie Alzheimerovy choroby (Akronym: Alzheimer)

Investor: Ministerstvo zdravotnictví ČR, Genetika a epidemiologie Alzheimerovy choroby

Citovat

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN, Vladimír JANOUT, Naim Akhtar KHAN a VJ BALCAR. CD36 gene polymorphism is associated with Alzheimer's disease. Biochimie. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2017, roč. 135, April, s. 46-53. ISSN 0300-9084. Dostupné z: https://dx.doi.org/10.1016/j.biochi.2017.01.009.

@article{1406153,
   author = {Šerý, Omar and Janoutova, J. and Ewerlingová, Laura and Hálová, Alice and Lochman, Jan and Janout, Vladimír and Khan, Naim Akhtar and Balcar, VJ},
   article_location = {Paris},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.biochi.2017.01.009},
   keywords = {Polymorphism; Association; CD36; Gene; ApoE; MMSE},
   language = {eng},
   issn = {0300-9084},
   journal = {Biochimie},
   title = {CD36 gene polymorphism is associated with Alzheimer's disease},
   volume = {135},
   year = {2017}
}

TY  - JOUR
ID  - 1406153
AU  - Šerý, Omar - Janoutova, J. - Ewerlingová, Laura - Hálová, Alice - Lochman, Jan - Janout, Vladimír - Khan, Naim Akhtar - Balcar, VJ
PY  - 2017
TI  - CD36 gene polymorphism is associated with Alzheimer's disease
JF  - Biochimie
VL  - 135
IS  - April
SP  - 46-53
EP  - 46-53
PB  - Elsevier France- editions Scientifiques Medicales Elsevier
SN  - 03009084
KW  - Polymorphism
KW  - Association
KW  - CD36
KW  - Gene
KW  - ApoE
KW  - MMSE
N2  - CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
ER  -

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN, Vladimír JANOUT, Naim Akhtar KHAN a VJ BALCAR. CD36 gene polymorphism is associated with Alzheimer's disease. \textit{Biochimie}. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2017, roč.~135, April, s.~46-53. ISSN~0300-9084. Dostupné z: https://dx.doi.org/10.1016/j.biochi.2017.01.009.

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