Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I

SVÁTKOVÁ, Alena, Bryon MUELLER, Petr BEDNAŘÍK, Carol NGUYEN, Lubomír VOJTÍŠEK, Silvia MANGIA, Mikko NISSI, Shalom MICHAELI a Igor NESTRAŠIL. Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I. In Joint annual meeting ISMRM-ESMRMB 2018. 2018.

Základní údaje

Originální název

Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I

Název anglicky

Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I

Autoři

SVÁTKOVÁ, Alena, Bryon MUELLER, Petr BEDNAŘÍK, Carol NGUYEN, Lubomír VOJTÍŠEK, Silvia MANGIA, Mikko NISSI, Shalom MICHAELI a Igor NESTRAŠIL

Vydání

Joint annual meeting ISMRM-ESMRMB 2018, 2018

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Další údaje

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

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Anotace

V originále

Mucopolysaccharidosis type I (MPSI) is an inherited metabolic disease with severe and attenuated disease subtypes. While both MPSI subtypes manifest pronounced morphological brain changes, little has been discovered about alterations of white matter (WM) microstructure. Here, we utilized rotating frame MRI contrasts along with DTI to detect WM alterations in 11 severe and 9 attenuated MPSI patients at 3T. T1ρ and RAFF4 detected WM differences between MPS subtypes that were not depicted by DTI. Outcomes demonstrate an exceptional sensitivity of rotating frame methods to probe WM microstructure in MPSI.

Anglicky

Mucopolysaccharidosis type I (MPSI) is an inherited metabolic disease with severe and attenuated disease subtypes. While both MPSI subtypes manifest pronounced morphological brain changes, little has been discovered about alterations of white matter (WM) microstructure. Here, we utilized rotating frame MRI contrasts along with DTI to detect WM alterations in 11 severe and 9 attenuated MPSI patients at 3T. T1ρ and RAFF4 detected WM differences between MPS subtypes that were not depicted by DTI. Outcomes demonstrate an exceptional sensitivity of rotating frame methods to probe WM microstructure in MPSI.