WADDINGTON, John L., Stanislav KATINA, Colm M. P. O’TUATHAIGH a Adrian W. BOWMAN. Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia. Current Behavioral Neuroscience Reports, Springer, 2017, roč. 4, č. 4, s. 322-330. ISSN 2196-2979. doi:10.1007/s40473-017-0136-3.
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Základní údaje
Originální název Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia
Autoři WADDINGTON, John L. (372 Irsko), Stanislav KATINA (703 Slovensko, garant, domácí), Colm M. P. O’TUATHAIGH (372 Irsko) a Adrian W. BOWMAN (826 Spojené království).
Vydání Current Behavioral Neuroscience Reports, Springer, 2017, 2196-2979.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Statistics and probability
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
WWW URL
Kód RIV RIV/00216224:14310/17:00100044
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.1007/s40473-017-0136-3
Klíčová slova anglicky Neurodevelopmental disorders; Craniofacial dysmorphology; Schizophrenia; Mouse models; 3D facial imaging; Geometric morphometrics; Asymmetry
Štítky NZ, rivok
Změnil Změnil: doc. PaedDr. RNDr. Stanislav Katina, Ph.D., učo 111465. Změněno: 22. 2. 2018 09:50.
Anotace
Purpose of Review In the context of human developmental conditions, we review the conceptualisation of schizophrenia as a neurodevelopmental disorder, the status of craniofacial dysmorphology as a clinically accessible index of brain dysmorphogenesis, the ability of genetically modified mouse models of craniofacial dysmorphology to inform on the underlying dysmorphogenic process and how geometric morphometric techniques in mutant mice can extend quantitative analysis. Recent Findings Mutant mice with disruption of neuregulin-1, a gene associated meta-analytically with risk for schizophrenia, constitute proof-of-concept studies of murine facial dysmorphology in a manner analogous to clinical studies in schizophrenia. Geometric morphometric techniques informed on the topography of facial dysmorphology and identified asymmetry therein. Summary Targeted disruption in mice of genes involved in individual components of developmental processes and analysis of resultant facial dysmorphology using geometric morphometrics can inform on mechanisms of dysmorphogenesis at levels of incisiveness not possible in human subjects.
VytisknoutZobrazeno: 21. 9. 2019 07:11